Detailed information of TA system TA186293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 138652..139275
• Replicon: chromosome
• Accession: NZ_CP067412
• Organism: Pseudomonas sp. HS6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: JJN09_RS00675
• Protein ID: WP_007957952.1
• Coordinates: 138652..138831 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JJN09_RS00680
• Protein ID: WP_085710213.1
• Coordinates: 138868..139275 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJN09_RS00645 (JJN09_00645)	133853..134116	-	264	WP_249485019.1	hypothetical protein	-
JJN09_RS00650 (JJN09_00650)	134324..135811	+	1488	WP_249485020.1	sensor domain-containing diguanylate cyclase	-
JJN09_RS00655 (JJN09_00655)	135804..136034	+	231	WP_249485021.1	cysteine-rich CWC family protein	-
JJN09_RS00660 (JJN09_00660)	136068..136760	+	693	WP_249485022.1	pseudouridine synthase	-
JJN09_RS00665 (JJN09_00665)	137077..137961	+	885	WP_249485023.1	alpha/beta hydrolase	-
JJN09_RS00675 (JJN09_00675)	138652..138831	+	180	WP_007957952.1	type II toxin-antitoxin system HicA family toxin	Toxin
JJN09_RS00680 (JJN09_00680)	138868..139275	+	408	WP_085710213.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
JJN09_RS00685 (JJN09_00685)	139511..140239	+	729	WP_249485024.1	class I SAM-dependent methyltransferase	-
JJN09_RS00690 (JJN09_00690)	140279..141049	-	771	WP_249485025.1	trans-aconitate 2-methyltransferase	-
JJN09_RS00695 (JJN09_00695)	141424..141927	+	504	WP_007957947.1	inclusion body family protein	-
JJN09_RS00700 (JJN09_00700)	142051..142590	+	540	WP_249485026.1	AidA/PixA family protein	-
JJN09_RS00705 (JJN09_00705)	142735..143145	+	411	WP_249485027.1	low affinity iron permease family protein	-
JJN09_RS00710 (JJN09_00710)	143194..143697	-	504	WP_249485028.1	DUF4142 domain-containing protein	-
JJN09_RS00715 (JJN09_00715)	143773..143931	-	159	WP_249485029.1	KGG domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	130964..148085	17121

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6660.91 Da
• Isoelectric Point: 11.4113

>T186293 WP_007957952.1 NZ_CP067412:138652-138831 [Pseudomonas sp. HS6]
VNSRFLIGQLVADGWYLVRVRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL

Nucleotide

• Length: 180 bp

>T186293 NZ_CP089313:c4547937-4547563 [Salmonella enterica subsp. enterica serovar Indiana]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAGAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAGCGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14542.56 Da
• Isoelectric Point: 4.5801

>AT186293 WP_085710213.1 NZ_CP067412:138868-139275 [Pseudomonas sp. HS6]
MLYPIAISVGDEGHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Nucleotide

• Length: 408 bp

>AT186293 NZ_CP089313:c4548179-4547937 [Salmonella enterica subsp. enterica serovar Indiana]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA