Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 20095..20620 | Replicon | plasmid psLT |
| Accession | NZ_CP067398 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | JJB81_RS23260 | Protein ID | WP_001159863.1 |
| Coordinates | 20315..20620 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | JJB81_RS23255 | Protein ID | WP_000813641.1 |
| Coordinates | 20095..20313 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJB81_RS23230 (JJB81_23225) | 15382..15763 | + | 382 | Protein_20 | YgiW/YdeI family stress tolerance OB fold protein | - |
| JJB81_RS23235 (JJB81_23230) | 15932..16376 | + | 445 | Protein_21 | tyrosine-type recombinase/integrase | - |
| JJB81_RS23240 (JJB81_23235) | 16635..17624 | - | 990 | WP_210138968.1 | RepB family plasmid replication initiator protein | - |
| JJB81_RS23245 (JJB81_23240) | 18118..18414 | - | 297 | WP_001687482.1 | hypothetical protein | - |
| JJB81_RS23895 | 18426..18854 | + | 429 | Protein_24 | hypothetical protein | - |
| JJB81_RS23250 (JJB81_23245) | 18898..19419 | - | 522 | WP_010999942.1 | hypothetical protein | - |
| JJB81_RS23255 (JJB81_23250) | 20095..20313 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| JJB81_RS23260 (JJB81_23255) | 20315..20620 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| JJB81_RS23265 (JJB81_23260) | 20622..20912 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| JJB81_RS23270 (JJB81_23265) | 20909..21430 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| JJB81_RS23275 (JJB81_23270) | 21465..22247 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| JJB81_RS23280 (JJB81_23275) | 22256..22807 | + | 552 | WP_000545754.1 | EAL domain-containing protein | - |
| JJB81_RS23285 (JJB81_23280) | 22994..23482 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| JJB81_RS23290 (JJB81_23285) | 23476..23961 | + | 486 | WP_000905606.1 | membrane protein | - |
| JJB81_RS23295 (JJB81_23290) | 24238..24525 | - | 288 | WP_071530243.1 | hypothetical protein | - |
| JJB81_RS23300 (JJB81_23295) | 24681..25241 | + | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB | 1..93938 | 93938 | |
| - | flank | IS/Tn | - | - | 25308..25658 | 350 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T186264 WP_001159863.1 NZ_CP067398:20315-20620 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T186264 NZ_CP089309:c1228485-1228111 [Thiocapsa bogorovii]
GTGATCCCGGTCGATACCTCCGTTTGGGTCGATCACCTGCGCAGCGGCGATGCCCCGCTGGCGGCAAGGCTCGAAGCCGC
GAGCGTCGCCATGCGCCCGATGGTGCTCGGCGAACTGGTCTGCGGGAATCTCAAGGACCGCCAAACCCTCCTCGCCCTGT
GGCGCAACCTGCCGCAGCTTCCGGCGGCCACCGATGCCGAGGCCCTGTTCTTTTTGGTACGCAACCGCCTGTTGGGGCGT
GGCATCGGCTATAACGGCGTGCACCTGCTCGCATCCGTTTCGCTGCATGCCCGGGCCAGGCTTTGGACCCGCGACAGACG
CCTGCGGGCGACCGCGGAACAATTGGGCCTGGCCCACCCGGAGCCGGACGCCTGA
GTGATCCCGGTCGATACCTCCGTTTGGGTCGATCACCTGCGCAGCGGCGATGCCCCGCTGGCGGCAAGGCTCGAAGCCGC
GAGCGTCGCCATGCGCCCGATGGTGCTCGGCGAACTGGTCTGCGGGAATCTCAAGGACCGCCAAACCCTCCTCGCCCTGT
GGCGCAACCTGCCGCAGCTTCCGGCGGCCACCGATGCCGAGGCCCTGTTCTTTTTGGTACGCAACCGCCTGTTGGGGCGT
GGCATCGGCTATAACGGCGTGCACCTGCTCGCATCCGTTTCGCTGCATGCCCGGGCCAGGCTTTGGACCCGCGACAGACG
CCTGCGGGCGACCGCGGAACAATTGGGCCTGGCCCACCCGGAGCCGGACGCCTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT186264 WP_000813641.1 NZ_CP067398:20095-20313 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT186264 NZ_CP089309:c1228682-1228482 [Thiocapsa bogorovii]
ATGCGTACCACCCTCAACATCGACGACGACCTGCTCCAGCGCGCCCGGGACCTCTCCGGCATGCAGGAGAAGACCGCCCT
GATCCGCGAAGGACTCAAGGCCCTGATCGAGCGGGAGAGCGCCCGCCGCCTCGCCAGGCTCGGGGGCTCCGAGCCCGGGT
TGGAACCCATCCCCCGACGACGCGTCGAGACTGGCGGGTGA
ATGCGTACCACCCTCAACATCGACGACGACCTGCTCCAGCGCGCCCGGGACCTCTCCGGCATGCAGGAGAAGACCGCCCT
GATCCGCGAAGGACTCAAGGCCCTGATCGAGCGGGAGAGCGCCCGCCGCCTCGCCAGGCTCGGGGGCTCCGAGCCCGGGT
TGGAACCCATCCCCCGACGACGCGTCGAGACTGGCGGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |