Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4724426..4725002 Replicon chromosome
Accession NZ_CP067397
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag JJB81_RS22765 Protein ID WP_001131963.1
Coordinates 4724426..4724713 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag JJB81_RS22770 Protein ID WP_000063142.1
Coordinates 4724700..4725002 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB81_RS22755 (4719536) 4719536..4723045 - 3510 WP_210138880.1 type I restriction-modification system endonuclease -
JJB81_RS22760 (4723243) 4723243..4724157 + 915 WP_000290512.1 restriction endonuclease -
JJB81_RS22765 (4724426) 4724426..4724713 + 288 WP_001131963.1 BrnT family toxin Toxin
JJB81_RS22770 (4724700) 4724700..4725002 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
JJB81_RS22775 (4725077) 4725077..4726033 - 957 WP_000187839.1 GTPase -
JJB81_RS22780 (4726044) 4726044..4726247 - 204 WP_000460616.1 YbdD/YjiX family protein -
JJB81_RS22785 (4726342) 4726342..4728492 - 2151 WP_000379927.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T186263 WP_001131963.1 NZ_CP067397:4724426-4724713 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T186263 NZ_CP089309:c1223783-1223505 [Thiocapsa bogorovii]
ATGATCAAGACGTTCCGCTGTCGAGACACGGAGGCGTTGTTCTCGGCACGGCGCGTTGCGCGGTTCGCCCATATTGAACG
CGCGGCGTTGCGCAAGCTCGTCCAGCTCAATCTGGCGCGTGTCATCGACGACATGCGCGCGCCTCCTGGCAACCGGCTGG
AGTCCTTGAAGGGTGATCGCGCCGGACAGTGGAGCGTTCGGATCAATGCGCAGTGGCGGCTGTGTTTCCGCTTTTCGGAC
GGCGACGCCCTGGATGTCGAAATCGTCGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT186263 WP_000063142.1 NZ_CP067397:4724700-4725002 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT186263 NZ_CP089309:c1223492-1223190 [Thiocapsa bogorovii]
ATGACTCGGGAGCTGGCGCCGGTTTCTCCCGGCGAGATGCTGATGGAGGAGTTCCTCAAGCCGCTGGCGCTGTCGCAGTA
TGCGTTGGCTCGGGCGGTGCATGTGCCGCCGCGGCGGATCAACGAGATCGTGCACGGCAAGCGTGCGGTGACGGCGGATA
CCGACCTGCGTCTGTGCCGCTTCTTCGGCCTGTCGGAAGGCTGGTGGCTGCGCCTGCAGGCCGACTATGACATTGCCCTT
GCCAAGGAAAGTATGGCCGACGTACTCAGCGAGATCGAGCCCTTGCCGCGTGGTCGTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References