Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4630226..4630742 Replicon chromosome
Accession NZ_CP067397
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000

Toxin (Protein)


Gene name relE Uniprot ID A0A0R9NWE9
Locus tag JJB81_RS22370 Protein ID WP_000220579.1
Coordinates 4630458..4630742 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag JJB81_RS22365 Protein ID WP_000212724.1
Coordinates 4630226..4630468 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB81_RS22345 (4625246) 4625246..4626379 + 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -
JJB81_RS22350 (4626363) 4626363..4627481 + 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
JJB81_RS22355 (4627478) 4627478..4628218 + 741 WP_210138870.1 KDGP aldolase family protein -
JJB81_RS22360 (4628235) 4628235..4630148 + 1914 WP_001212137.1 BglG family transcription antiterminator -
JJB81_RS22365 (4630226) 4630226..4630468 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JJB81_RS22370 (4630458) 4630458..4630742 + 285 WP_000220579.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJB81_RS22375 (4630746) 4630746..4631210 - 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JJB81_RS22380 (4631331) 4631331..4633469 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
JJB81_RS22385 (4633878) 4633878..4635530 - 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10884.70 Da        Isoelectric Point: 10.0482

>T186262 WP_000220579.1 NZ_CP067397:4630458-4630742 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDTNKRL

Download         Length: 285 bp

>T186262 NZ_CP089309:c1223131-1222877 [Thiocapsa bogorovii]
ATGCAAACCATCACCTTCTCCGATGCCCGCAATCAACTGAAGCAAGTGCTTGATCGCGTAGCAGACGACGCGGACTACAC
GGTCATCACCCGTCGAGATGCTGAAGACGCGGTCGTGATGTCCCTCGACAGCTTCAATAGTCTGATGGAGACGGTCCACC
TGCTTCGCTCACCGGCCAACGCCGAGCATCTCGCCCGCTCCATTGCCCAATACCGCCAGGGACAGACCGCCGAGCATCCG
TTGCAGCATGACTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT186262 WP_000212724.1 NZ_CP067397:4630226-4630468 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT186262 NZ_CP089309:c1223492-1223190 [Thiocapsa bogorovii]
ATGACTCGGGAGCTGGCGCCGGTTTCTCCCGGCGAGATGCTGATGGAGGAGTTCCTCAAGCCGCTGGCGCTGTCGCAGTA
TGCGTTGGCTCGGGCGGTGCATGTGCCGCCGCGGCGGATCAACGAGATCGTGCACGGCAAGCGTGCGGTGACGGCGGATA
CCGACCTGCGTCTGTGCCGCTTCTTCGGCCTGTCGGAAGGCTGGTGGCTGCGCCTGCAGGCCGACTATGACATTGCCCTT
GCCAAGGAAAGTATGGCCGACGTACTCAGCGAGATCGAGCCCTTGCCGCGTGGTCGTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NWE9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References