Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 3776519..3777279 | Replicon | chromosome |
| Accession | NZ_CP067397 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | JJB81_RS18355 | Protein ID | WP_000533909.1 |
| Coordinates | 3776519..3777004 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | M7RHS4 |
| Locus tag | JJB81_RS18360 | Protein ID | WP_000965886.1 |
| Coordinates | 3776992..3777279 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJB81_RS18325 (3771589) | 3771589..3772251 | + | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
| JJB81_RS18330 (3772470) | 3772470..3773444 | + | 975 | WP_000804674.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| JJB81_RS18335 (3773494) | 3773494..3774204 | - | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| JJB81_RS18340 (3774643) | 3774643..3774933 | + | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| JJB81_RS18345 (3775222) | 3775222..3775434 | + | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| JJB81_RS18350 (3775608) | 3775608..3776147 | + | 540 | WP_000047149.1 | copper-binding periplasmic metallochaperone CueP | - |
| JJB81_RS18355 (3776519) | 3776519..3777004 | - | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| JJB81_RS18360 (3776992) | 3776992..3777279 | - | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
| JJB81_RS18365 (3777457) | 3777457..3777924 | - | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
| JJB81_RS18370 (3778096) | 3778096..3778371 | - | 276 | Protein_3605 | IS3 family transposase | - |
| JJB81_RS18375 (3778553) | 3778553..3780622 | - | 2070 | WP_001291736.1 | glycine--tRNA ligase subunit beta | - |
| JJB81_RS18380 (3780632) | 3780632..3781543 | - | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
| JJB81_RS18385 (3781682) | 3781682..3781984 | - | 303 | WP_000605590.1 | YsaB family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T186258 WP_000533909.1 NZ_CP067397:c3777004-3776519 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
>T186258 NZ_CP089309:469466-469873 [Thiocapsa bogorovii]
ATGCCGCGCTACATGCTCGATACGAACATGTGTGTCTATCTGATCAAGCATCAGCCCGAGATCGTCGCCCGACGCTTTGC
CCAATGTCATGTCGGCGATGTCGTGATGTCCGCGATCACCTTCGCCGAGCTGGAATATGGCGTCGCGGTCGCGGCCCATC
CGGAAACGGAACGCGGTTATCTGGACAGCCTGATTCAAGACATCCCGGTTGCACCCTTCGATGTGGCAGCGGGCCGAGCC
TATGCGTCCGTTAGACTCGCGACACGCGACAGCCGGAAAAACGCTCTCGACAAGCTGATTGCGGCCCATGCACAGTCGCT
CAACGTCACGCTCGTCACAAACAACACGAAAGACTTCGCCGGATATCCCGGCGTCATGATCGAAAACTGGCTGATGCCAA
ACACCTGA
ATGCCGCGCTACATGCTCGATACGAACATGTGTGTCTATCTGATCAAGCATCAGCCCGAGATCGTCGCCCGACGCTTTGC
CCAATGTCATGTCGGCGATGTCGTGATGTCCGCGATCACCTTCGCCGAGCTGGAATATGGCGTCGCGGTCGCGGCCCATC
CGGAAACGGAACGCGGTTATCTGGACAGCCTGATTCAAGACATCCCGGTTGCACCCTTCGATGTGGCAGCGGGCCGAGCC
TATGCGTCCGTTAGACTCGCGACACGCGACAGCCGGAAAAACGCTCTCGACAAGCTGATTGCGGCCCATGCACAGTCGCT
CAACGTCACGCTCGTCACAAACAACACGAAAGACTTCGCCGGATATCCCGGCGTCATGATCGAAAACTGGCTGATGCCAA
ACACCTGA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT186258 WP_000965886.1 NZ_CP067397:c3777279-3776992 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
>AT186258 NZ_CP089309:469230-469466 [Thiocapsa bogorovii]
ATGCGCATCACGAAAGCGTTTAAAAATGGTCATTCGCAAGCCGTGCGGATCCCCGCCGAGCTGGCTTTCGAGCGCATGGA
TATTGAACTGGAGATCGAAAGATGCGGCGACGAACTGCGTATTCGCCCCGCACGGCGGTCATTGGCAGGGGTATTGACCA
AGTTTGCCCGATTCTCCCCTGACTTCATGGCGGACGGTCGCGGCGAGCAAGAGCAGGACGGTCGGGATCGCCTCTGA
ATGCGCATCACGAAAGCGTTTAAAAATGGTCATTCGCAAGCCGTGCGGATCCCCGCCGAGCTGGCTTTCGAGCGCATGGA
TATTGAACTGGAGATCGAAAGATGCGGCGACGAACTGCGTATTCGCCCCGCACGGCGGTCATTGGCAGGGGTATTGACCA
AGTTTGCCCGATTCTCCCCTGACTTCATGGCGGACGGTCGCGGCGAGCAAGAGCAGGACGGTCGGGATCGCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V2JDX2 |