Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3776519..3777279 Replicon chromosome
Accession NZ_CP067397
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag JJB81_RS18355 Protein ID WP_000533909.1
Coordinates 3776519..3777004 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag JJB81_RS18360 Protein ID WP_000965886.1
Coordinates 3776992..3777279 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB81_RS18325 (3771589) 3771589..3772251 + 663 WP_000747548.1 OmpA family lipoprotein -
JJB81_RS18330 (3772470) 3772470..3773444 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
JJB81_RS18335 (3773494) 3773494..3774204 - 711 WP_000190524.1 DUF3053 domain-containing protein -
JJB81_RS18340 (3774643) 3774643..3774933 + 291 WP_000455790.1 HTH-type transcriptional regulator -
JJB81_RS18345 (3775222) 3775222..3775434 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
JJB81_RS18350 (3775608) 3775608..3776147 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
JJB81_RS18355 (3776519) 3776519..3777004 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
JJB81_RS18360 (3776992) 3776992..3777279 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
JJB81_RS18365 (3777457) 3777457..3777924 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
JJB81_RS18370 (3778096) 3778096..3778371 - 276 Protein_3605 IS3 family transposase -
JJB81_RS18375 (3778553) 3778553..3780622 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
JJB81_RS18380 (3780632) 3780632..3781543 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
JJB81_RS18385 (3781682) 3781682..3781984 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T186258 WP_000533909.1 NZ_CP067397:c3777004-3776519 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T186258 NZ_CP089309:469466-469873 [Thiocapsa bogorovii]
ATGCCGCGCTACATGCTCGATACGAACATGTGTGTCTATCTGATCAAGCATCAGCCCGAGATCGTCGCCCGACGCTTTGC
CCAATGTCATGTCGGCGATGTCGTGATGTCCGCGATCACCTTCGCCGAGCTGGAATATGGCGTCGCGGTCGCGGCCCATC
CGGAAACGGAACGCGGTTATCTGGACAGCCTGATTCAAGACATCCCGGTTGCACCCTTCGATGTGGCAGCGGGCCGAGCC
TATGCGTCCGTTAGACTCGCGACACGCGACAGCCGGAAAAACGCTCTCGACAAGCTGATTGCGGCCCATGCACAGTCGCT
CAACGTCACGCTCGTCACAAACAACACGAAAGACTTCGCCGGATATCCCGGCGTCATGATCGAAAACTGGCTGATGCCAA
ACACCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT186258 WP_000965886.1 NZ_CP067397:c3777279-3776992 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT186258 NZ_CP089309:469230-469466 [Thiocapsa bogorovii]
ATGCGCATCACGAAAGCGTTTAAAAATGGTCATTCGCAAGCCGTGCGGATCCCCGCCGAGCTGGCTTTCGAGCGCATGGA
TATTGAACTGGAGATCGAAAGATGCGGCGACGAACTGCGTATTCGCCCCGCACGGCGGTCATTGGCAGGGGTATTGACCA
AGTTTGCCCGATTCTCCCCTGACTTCATGGCGGACGGTCGCGGCGAGCAAGAGCAGGACGGTCGGGATCGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References