Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3144790..3145450 Replicon chromosome
Accession NZ_CP067397
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag JJB81_RS15285 Protein ID WP_000244756.1
Coordinates 3144790..3145203 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag JJB81_RS15290 Protein ID WP_000351186.1
Coordinates 3145184..3145450 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB81_RS15265 (3140731) 3140731..3142464 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
JJB81_RS15270 (3142470) 3142470..3143183 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JJB81_RS15275 (3143207) 3143207..3144103 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
JJB81_RS15280 (3144216) 3144216..3144737 + 522 WP_001055885.1 flavodoxin FldB -
JJB81_RS15285 (3144790) 3144790..3145203 - 414 WP_000244756.1 protein YgfX Toxin
JJB81_RS15290 (3145184) 3145184..3145450 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
JJB81_RS15295 (3145700) 3145700..3146680 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
JJB81_RS15300 (3146796) 3146796..3147455 - 660 WP_000250289.1 hemolysin III family protein -
JJB81_RS15305 (3147619) 3147619..3147930 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
JJB81_RS15310 (3148089) 3148089..3149522 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T186255 WP_000244756.1 NZ_CP067397:c3145203-3144790 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T186255 NZ_CP089307:1379787-1380089 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCTGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCTT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTACATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTAAG
CAGCAAGATCTCATTTTGACCCTGGTTAGAACTGGATCTCATCATAACCTTTTGGGTAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT186255 WP_000351186.1 NZ_CP067397:c3145450-3145184 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186255 NZ_CP089307:1379525-1379794 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAAGAAACTCGCTTGAATATTCGTGTTGATCCGGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACTATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References