Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 528034..528654 Replicon chromosome
Accession NZ_CP067397
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JJB81_RS02395 Protein ID WP_001280991.1
Coordinates 528034..528252 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag JJB81_RS02400 Protein ID WP_000344807.1
Coordinates 528280..528654 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB81_RS02355 (523259) 523259..523828 + 570 WP_000779803.1 YbaY family lipoprotein -
JJB81_RS02360 (523861) 523861..524250 - 390 WP_000961285.1 MGMT family protein -
JJB81_RS02370 (524481) 524481..526031 - 1551 WP_210138930.1 EAL domain-containing protein -
JJB81_RS02375 (526256) 526256..526516 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
JJB81_RS02380 (526522) 526522..526662 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JJB81_RS02385 (526718) 526718..527188 - 471 WP_000136181.1 YlaC family protein -
JJB81_RS02390 (527313) 527313..527855 - 543 Protein_468 maltose O-acetyltransferase -
JJB81_RS02395 (528034) 528034..528252 - 219 WP_001280991.1 HHA domain-containing protein Toxin
JJB81_RS02400 (528280) 528280..528654 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
JJB81_RS02405 (529150) 529150..532299 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
JJB81_RS02410 (532322) 532322..533515 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T186243 WP_001280991.1 NZ_CP067397:c528252-528034 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T186243 NZ_CP089301:c5478145-5477822 [Novosphingobium kaempferiae]
GTGAAACGCGGCGATCTCGTGACGATCGCGGCGCCAGGCGATTTCGGCAAGCCGCGCCCGGCCCTCGTCGTCCAGTCCGA
CCGCTTCGATGCGACCGGCACGCTGACGGTGCTGCTGCTCTCCGGCACGCCGGTGGACGCGCCGCTGATCCGCGTGCCCG
TGGCGCCGACACCCGATAACGGCCTGCGCAAGCCCTCGCAGGTCATGGTCGACAAGGCCATGTCGGTGAAACGCGAGCGG
ATCGGCGCAACCATCGGTCAACTGGACGCCGAAACGATGCTGTCGGTGACGCGTTCGCTAGCGGTCTTCCTCGACATTGC
GTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT186243 WP_000344807.1 NZ_CP067397:c528654-528280 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT186243 NZ_CP089301:c5478363-5478142 [Novosphingobium kaempferiae]
ATGCCCGCACCTGTCAGCGAACGCGTCCGGAAGCGCCGCGATGCGCTGCGTGCCGCGGGGCTGCGTCCGATCCAGATCTG
GGTGCCGGACACGCGCAGGCCCGGGTTTGCCGAAGAATGCCGCAGGCAGGCCCTCGCCGTCGCTGCTGCCGATACCACCG
ATGCCGACCTCGACGACTTCCTTGACGCCGCGCTCGTCGACCTGGACGCCGAAGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References