Detailed information of TA system TA186237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 2850050..2850534
• Replicon: chromosome
• Accession: NZ_CP067394
• Organism: Cryobacterium sp. SO1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BJQ95_RS13425
• Protein ID: WP_130178724.1
• Coordinates: 2850050..2850316 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: BJQ95_RS13430
• Protein ID: WP_130178723.1
• Coordinates: 2850313..2850534 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJQ95_RS13410	2846118..2846387	-	270	WP_130178726.1	hypothetical protein	-
BJQ95_RS13415	2846431..2847060	-	630	WP_130178725.1	heme-binding protein	-
BJQ95_RS13420	2847617..2849758	-	2142	WP_205750204.1	hypothetical protein	-
BJQ95_RS13425	2850050..2850316	-	267	WP_130178724.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BJQ95_RS13430	2850313..2850534	-	222	WP_130178723.1	DUF6290 family protein	Antitoxin
BJQ95_RS13435	2850631..2851197	-	567	WP_240694877.1	hypothetical protein	-
BJQ95_RS13440	2851392..2852045	+	654	WP_130178722.1	hypothetical protein	-
BJQ95_RS13445	2852069..2852269	+	201	WP_130178721.1	hypothetical protein	-
BJQ95_RS13450	2852427..2854274	-	1848	WP_130178720.1	iron ABC transporter permease	-
BJQ95_RS13455	2854284..2855294	-	1011	WP_130178719.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-86)

Antitoxin

• Relaxosome protein TraY (4-42)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10466.80 Da
• Isoelectric Point: 9.9710

>T186237 WP_130178724.1 NZ_CP067394:c2850316-2850050 [Cryobacterium sp. SO1]
VTARWHVETTEQFDRQFRRLDRAVQRRVLTYLEGVEHLDDPRQRGKGLTASHSGVWRYRVGDYRILAQIRDDTMVVLALT
VDHRKDAY

Nucleotide

• Length: 267 bp

>T186237 NZ_CP089296:314908-315180 [Methylobacterium currus]
ATGAGGCTCACTTTCTCGGACGAAGCCTGGAACGAGTACCTGTTCTGGCAAAGCGAGAGCGAAGCCACGCTGCACCGGAT
CAACGATCTCATCAAAGAGGTCAAACGTACTCCCTTCACGGGAACAGGCGAGCCCGAGCCTTTGAAGTTCAAGCTCGAGG
GGTGGTGGTCGCGCCGGATCTCGGGAGAGCACAGGCTTGTCTATCGCGTGAGCGGTTCCGGCGCGGTCCAGACACTTGAG
ATCGCGCAGTGCCGGTGGCACTACGACGACTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8279.23 Da
• Isoelectric Point: 4.6677

>AT186237 WP_130178723.1 NZ_CP067394:c2850534-2850313 [Cryobacterium sp. SO1]
VTISIRLTLDEEERLEKLSQRTGRSKSFYVRAALRAHLTDLEDAFVADEAVDAFEAADRRSRPLSELKAESDL

Nucleotide

• Length: 222 bp

>AT186237 NZ_CP089296:314630-314911 [Methylobacterium currus]
TTGACGCATGTCAGCCTGACGGAATTGCGCCAGAGCATCGCAACGCATTTCGACCGGGTCGAGCGCGACCGGGAGGAACT
GGTGGTCACCCGCCAGGGCCATGAGCCCCTGGTTCTGCTTCCGCTCGCCGAGTTGGAGAGCTTGCGGGACACCCCTCACC
TCCTCGGTACCCCCGCCAAGGCGCGGCGCCTGATGCGGTCGATCGAACAGCTCGACGCAGGCCGAGGGGTCGAACGCTCG
CCGATCGAACCCGATCAGTCCAAGGACGCAGCCGAGGGATGA