Detailed information of TA system TA186236

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1402718..1403282
• Replicon: chromosome
• Accession: NZ_CP067394
• Organism: Cryobacterium sp. SO1

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: BJQ95_RS06560
• Protein ID: WP_130178541.1
• Coordinates: 1402718..1403065 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: BJQ95_RS06565
• Protein ID: WP_130178540.1
• Coordinates: 1403052..1403282 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJQ95_RS06545	1399179..1400015	-	837	WP_130178544.1	phosphonate ABC transporter ATP-binding protein	-
BJQ95_RS06550	1400075..1401019	-	945	WP_130178543.1	phosphate/phosphite/phosphonate ABC transporter substrate-binding protein	-
BJQ95_RS06555	1401302..1402537	+	1236	WP_130178542.1	low temperature requirement protein A	-
BJQ95_RS06560	1402718..1403065	-	348	WP_130178541.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
BJQ95_RS06565	1403052..1403282	-	231	WP_130178540.1	ribbon-helix-helix domain-containing protein	Antitoxin
BJQ95_RS06570	1403460..1403882	-	423	WP_130178539.1	YkvA family protein	-
BJQ95_RS06575	1403879..1404022	-	144	WP_165384987.1	hypothetical protein	-
BJQ95_RS06580	1404242..1405078	+	837	WP_130178538.1	pentapeptide repeat-containing protein	-
BJQ95_RS06585	1405229..1405432	+	204	WP_205750184.1	ribbon-helix-helix protein, CopG family	-
BJQ95_RS06590	1405429..1405806	+	378	WP_130178537.1	type II toxin-antitoxin system death-on-curing family toxin	-
BJQ95_RS06595	1406483..1406968	+	486	WP_130178536.1	SMI1/KNR4 family protein	-
BJQ95_RS06600	1407225..1407641	+	417	WP_240694855.1	DUF5684 domain-containing protein	-
BJQ95_RS06605	1407837..1408205	+	369	WP_130178535.1	aminoglycoside phosphotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1378665..1459420	80755

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12361.22 Da
• Isoelectric Point: 10.6439

>T186236 WP_130178541.1 NZ_CP067394:c1403065-1402718 [Cryobacterium sp. SO1]
MLRGEIRLVDLDPVRGSESSKRRPAVIVSNDRANSIAARLGRGVVTVVPVTSNTDRIFPFQALLPAGATGLPQDSKAQAE
QVRSIAVERLGAILGRAPADVMEQLDDALRLHLQL

Nucleotide

• Length: 348 bp

>T186236 NZ_CP089295:c824782-824372 [Methylobacterium currus]
GTGACGCCTCGCTACCTGCTCGATACGAACATCATCATAGCGCTTCGACGCAAGCGGCCACGCTCGGTCGTCGCCCGACT
GACGACGCTCGGCATCGGCGAAGCGGTCATGTCGCCGGTGACCTACGGAGAGCTGTGCTTCGGGGCGGAGAAGAGCGTGG
ATCGTGATGCCGCTTTCGCGGCTCTCGCCCGACTGGTTGCGGTCGTGCCAATCGCGATTGCCGAGCCCGACGAGACCGGC
CGCCGCTATGGCGCCATCCGAGCCAAACTCGGGCGTCAAGGTCAGATCATCGGCGGCAACGAACTCTGGATCGCCGCTCA
CGCCCTCGCGGCCGGGCTGACGCTCGTGACCGGGAACGTGGGCGAGTTCAGCCACGTGCCCGGCCTCACGATCGAGGATT
GGACGGCCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8200.08 Da
• Isoelectric Point: 4.2250

>AT186236 WP_130178540.1 NZ_CP067394:c1403282-1403052 [Cryobacterium sp. SO1]
MKISVSLPDEDVAVLDEYARAAGLSSRSAAVHHAVRMLRLPDLEQNYEAAWSEWESSGDLAVWSVTAADGIADAAR

Nucleotide

• Length: 231 bp

>AT186236 NZ_CP089295:c825006-824779 [Methylobacterium currus]
ATGGCCGTCGCGAAGCTCTTCATGTCCGGCGGGAGCCAAGCCGTCAGACTGCCGCGGGAATTTCGCTTCGACGGCAGCGC
GGTCGAGATTTTTCGCCGCGGCGACGAGGTCGTCCTGCGCGAGCGCCCAACCCATCTCTCCGTTCTCCTCGACATCATCG
ACAGCATGCCCGCCGACATGCTGACCGATCTGCATGATGGCCTACCGGAGCAGCGCGAGGGCCTGTGA