Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5674568..5675178 Replicon chromosome
Accession NZ_CP067391
Organism Klebsiella grimontii strain 5512.56

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E1GAR7
Locus tag JJJ11_RS29050 Protein ID WP_049086919.1
Coordinates 5674568..5674942 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JJJ11_RS29055 Protein ID WP_077253475.1
Coordinates 5674939..5675178 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJJ11_RS29035 (JJJ11_29020) 5671723..5672625 + 903 WP_209573712.1 formate dehydrogenase subunit beta -
JJJ11_RS29040 (JJJ11_29025) 5672622..5673257 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
JJJ11_RS29045 (JJJ11_29030) 5673601..5674530 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
JJJ11_RS29050 (JJJ11_29035) 5674568..5674942 - 375 WP_049086919.1 type II toxin-antitoxin system VapC family toxin Toxin
JJJ11_RS29055 (JJJ11_29040) 5674939..5675178 - 240 WP_077253475.1 CopG family transcriptional regulator Antitoxin
JJJ11_RS29060 (JJJ11_29045) 5675384..5676301 + 918 WP_024360706.1 alpha/beta hydrolase -
JJJ11_RS29065 (JJJ11_29050) 5676319..5677260 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
JJJ11_RS29070 (JJJ11_29055) 5677305..5677742 - 438 WP_024360707.1 D-aminoacyl-tRNA deacylase -
JJJ11_RS29075 (JJJ11_29060) 5677739..5678599 - 861 WP_004127107.1 virulence factor BrkB family protein -
JJJ11_RS29080 (JJJ11_29065) 5678593..5679192 - 600 WP_024360709.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14111.45 Da        Isoelectric Point: 8.4571

>T186235 WP_049086919.1 NZ_CP067391:c5674942-5674568 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWMEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

>T186235 NZ_CP089287:c2187624-2187274 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9293.49 Da        Isoelectric Point: 4.3142

>AT186235 WP_077253475.1 NZ_CP067391:c5675178-5674939 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEDGVEFERKLREEWQ

Download         Length: 240 bp

>AT186235 NZ_CP089287:c2187911-2187630 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References