186234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 5095528..5096231 Replicon chromosome
Accession NZ_CP067391
Organism Klebsiella grimontii strain 5512.56

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag JJJ11_RS26325 Protein ID WP_049017155.1
Coordinates 5095528..5095869 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag JJJ11_RS26330 Protein ID WP_209573618.1
Coordinates 5095890..5096231 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJJ11_RS26300 (JJJ11_26285) 5091439..5091930 + 492 WP_228732640.1 DNA/RNA non-specific endonuclease -
JJJ11_RS26305 (JJJ11_26290) 5092220..5092543 + 324 WP_209573613.1 endoribonuclease SymE -
JJJ11_RS26310 (JJJ11_26295) 5092690..5093124 + 435 WP_209573615.1 VOC family protein -
JJJ11_RS26315 (JJJ11_26300) 5093289..5094032 + 744 WP_209573616.1 hypothetical protein -
JJJ11_RS26320 (JJJ11_26305) 5094262..5095269 - 1008 WP_049017154.1 restriction endonuclease -
JJJ11_RS26325 (JJJ11_26310) 5095528..5095869 - 342 WP_049017155.1 TA system toxin CbtA family protein Toxin
JJJ11_RS26330 (JJJ11_26315) 5095890..5096231 - 342 WP_209573618.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JJJ11_RS26335 (JJJ11_26320) 5096242..5096784 - 543 WP_209573620.1 DNA repair protein RadC -
JJJ11_RS26340 (JJJ11_26325) 5096797..5097240 - 444 WP_047365977.1 antirestriction protein -
JJJ11_RS26345 (JJJ11_26330) 5097271..5098092 - 822 WP_049017158.1 DUF932 domain-containing protein -
JJJ11_RS26350 (JJJ11_26335) 5098213..5098686 - 474 WP_049017159.1 hypothetical protein -
JJJ11_RS26355 (JJJ11_26340) 5098758..5099210 - 453 WP_077258843.1 hypothetical protein -
JJJ11_RS26360 (JJJ11_26345) 5099246..5099962 - 717 WP_048291793.1 WYL domain-containing protein -
JJJ11_RS26365 (JJJ11_26350) 5100206..5101081 - 876 WP_209573621.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5092690..5105776 13086


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12724.66 Da        Isoelectric Point: 6.4514

>T186234 WP_049017155.1 NZ_CP067391:c5095869-5095528 [Klebsiella grimontii]
MKTLPATTPQAATLCLSPVAVWQMLLACLLEQHYGLTLNDTPFSDETVIQEHIDAGITLADAVNFLVEKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Download         Length: 342 bp

>T186234 NZ_CP089287:1396463-1397209 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCGCTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGATGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.62 Da        Isoelectric Point: 7.0267

>AT186234 WP_209573618.1 NZ_CP067391:c5096231-5095890 [Klebsiella grimontii]
MKYTDSENDSFLKWGLNRNVTPCFVARLVQEGNRLHYLADRASITGKFSEAECLKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTREADTLGSCGYVYIAVYPTHR

Download         Length: 342 bp

>AT186234 NZ_CP089287:1397210-1397380 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References