Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4397454..4398073 Replicon chromosome
Accession NZ_CP067391
Organism Klebsiella grimontii strain 5512.56

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag JJJ11_RS23080 Protein ID WP_004099646.1
Coordinates 4397855..4398073 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag JJJ11_RS23075 Protein ID WP_004129911.1
Coordinates 4397454..4397828 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJJ11_RS23065 (JJJ11_23055) 4392623..4393816 + 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JJJ11_RS23070 (JJJ11_23060) 4393839..4396985 + 3147 WP_004848339.1 multidrug efflux RND transporter permease subunit AcrB -
JJJ11_RS23075 (JJJ11_23065) 4397454..4397828 + 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
JJJ11_RS23080 (JJJ11_23070) 4397855..4398073 + 219 WP_004099646.1 HHA domain-containing protein Toxin
JJJ11_RS23085 (JJJ11_23075) 4398235..4398801 + 567 WP_004136050.1 maltose O-acetyltransferase -
JJJ11_RS29690 4398773..4398907 - 135 WP_223226911.1 hypothetical protein -
JJJ11_RS23090 (JJJ11_23080) 4398928..4399398 + 471 WP_004136048.1 YlaC family protein -
JJJ11_RS23095 (JJJ11_23085) 4399373..4400827 - 1455 WP_154932232.1 PLP-dependent aminotransferase family protein -
JJJ11_RS23100 (JJJ11_23090) 4400928..4401626 + 699 WP_004136044.1 GNAT family protein -
JJJ11_RS23105 (JJJ11_23095) 4401623..4401763 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
JJJ11_RS23110 (JJJ11_23100) 4401763..4402026 - 264 WP_004129897.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T186232 WP_004099646.1 NZ_CP067391:4397855-4398073 [Klebsiella grimontii]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T186232 NZ_CP089283:c259738-259466 [Helicobacter pylori]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAATGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGGAAATTTAGCCACAGAGCAACCCCTAGAACCCAAATACAAAGACCACCCACTCAAAGGCGCTTTAA
AAGACTTTAGGGAATGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACTCTTTTTTTA
GTAAGGCTAGGCAGTCATAGCGAGCTGTTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT186232 WP_004129911.1 NZ_CP067391:4397454-4397828 [Klebsiella grimontii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT186232 NZ_CP089283:c259418-259167 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAAACAGCTTTTTAATCTCATCAATCAATTAGAGCAAAA
AATCAGCCAAGCTTTTGATGATAAAAGAGGTTGTTGTTTGGGGCATGAGATCCCAAACCTTGAAACGCAACAAGCCATAA
GAGGTGCGTTAAATGGCGAAAATTTAGAGGTTATTGAAGATTTTTCTGCATGGGCCAATGAAATCAAAAAGGAAGTGAAT
GCTGAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References