Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 881970..882679 Replicon chromosome
Accession NZ_CP067391
Organism Klebsiella grimontii strain 5512.56

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag JJJ11_RS06660 Protein ID WP_029602169.1
Coordinates 882356..882679 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JJJ11_RS06655 Protein ID WP_098067228.1
Coordinates 881970..882320 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJJ11_RS06625 (JJJ11_06625) 877148..878299 - 1152 WP_141522397.1 hypothetical protein -
JJJ11_RS06630 (JJJ11_06630) 878397..879290 + 894 WP_209573826.1 50S ribosome-binding GTPase -
JJJ11_RS06635 (JJJ11_06635) 879575..880252 + 678 WP_209573828.1 hypothetical protein -
JJJ11_RS06640 (JJJ11_06640) 880348..881169 + 822 WP_032437350.1 DUF932 domain-containing protein -
JJJ11_RS06645 (JJJ11_06645) 881240..881713 + 474 WP_209573830.1 DNA repair protein RadC -
JJJ11_RS06650 (JJJ11_06650) 881728..881949 + 222 WP_098067229.1 DUF987 domain-containing protein -
JJJ11_RS06655 (JJJ11_06655) 881970..882320 + 351 WP_098067228.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JJJ11_RS06660 (JJJ11_06660) 882356..882679 + 324 WP_029602169.1 TA system toxin CbtA family protein Toxin
JJJ11_RS06665 (JJJ11_06665) 883047..883397 + 351 WP_004134443.1 transcriptional regulator -
JJJ11_RS06670 (JJJ11_06670) 883450..884742 + 1293 WP_024358597.1 arsenic transporter -
JJJ11_RS06675 (JJJ11_06675) 884752..885177 + 426 WP_024358596.1 glutaredoxin-dependent arsenate reductase -
JJJ11_RS29595 885370..885528 + 159 WP_004134456.1 AAA family ATPase -
JJJ11_RS06685 (JJJ11_06685) 885570..887219 - 1650 WP_024358595.1 OFA family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 846623..882679 36056


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-106)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12271.15 Da        Isoelectric Point: 6.4617

>T186222 WP_029602169.1 NZ_CP067391:882356-882679 [Klebsiella grimontii]
MNTLPAINQRAVQPYPSPVVVWQMLLARLLEQHYGLTLNDTPFSDEAVIKGHIEAGITLVDAVNFLVEKYELVRVDQRGF
SWQEQAPYLTIVDIMRARRYLGITNRS

Download         Length: 324 bp

>T186222 NZ_CP089272:4837656-4837997 [Escherichia coli O157:H7]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 12916.67 Da        Isoelectric Point: 5.5068

>AT186222 WP_098067228.1 NZ_CP067391:881970-882320 [Klebsiella grimontii]
MSNKTLTANDDTAEPWWGLSRNVIPCFGARMVQEGNRLHYLADRASITGQFNEADLLHLDQAFPVLLKQVELMLTSGELN
PRHQHCVTLYAKGLTCEADTLGSCGYVYIAIYPTQS

Download         Length: 351 bp

>AT186222 NZ_CP089272:c4837661-4837585 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References