Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833527..834184 Replicon chromosome
Accession NZ_CP067391
Organism Klebsiella grimontii strain 5512.56

Toxin (Protein)


Gene name cptA Uniprot ID A0A9E1DA00
Locus tag JJJ11_RS06385 Protein ID WP_024358614.1
Coordinates 833774..834184 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag JJJ11_RS06380 Protein ID WP_004124953.1
Coordinates 833527..833793 (+) Length 89 a.a.

Genomic Context

JJJ11_RS06360JJJ11_RS06365JJJ11_RS06380JJJ11_RS06385JJJ11_RS06395JJJ11_RS06400JJJ11_RS06405JJJ11_RS06355JJJ11_RS06370JJJ11_RS06375JJJ11_RS06390
Location: 829749..830060 (312 bp)
Type: Others
Protein ID: WP_004133599.1
Location: 830223..830882 (660 bp)
Type: Others
Protein ID: WP_004124978.1
Location: 833527..833793 (267 bp)
Type: Antitoxin
Protein ID: WP_004124953.1
Location: 833774..834184 (411 bp)
Type: Toxin
Protein ID: WP_024358614.1
Location: 834836..835732 (897 bp)
Type: Others
Protein ID: WP_209573824.1
Location: 835755..836468 (714 bp)
Type: Others
Protein ID: WP_004134425.1
Location: 836474..838207 (1734 bp)
Type: Others
Protein ID: WP_098066860.1
Location: 828970..829698 (729 bp)
Type: Others
Protein ID: WP_024358621.1
Location: 831068..832048 (981 bp)
Type: Others
Protein ID: WP_049130515.1
Location: 832299..833282 (984 bp)
Type: Others
Protein ID: WP_024358615.1
Location: 834193..834714 (522 bp)
Type: Others
Protein ID: WP_024358613.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JJJ11_RS06355 (JJJ11_06355)828970..829698-729WP_024358621.1MurR/RpiR family transcriptional regulator-
JJJ11_RS06360 (JJJ11_06360)829749..830060+312WP_004133599.1N(4)-acetylcytidine aminohydrolase-
JJJ11_RS06365 (JJJ11_06365)830223..830882+660WP_004124978.1hemolysin III family protein-
JJJ11_RS06370 (JJJ11_06370)831068..832048-981WP_049130515.1IS110 family transposase-
JJJ11_RS06375 (JJJ11_06375)832299..833282-984WP_024358615.1tRNA-modifying protein YgfZ-
JJJ11_RS06380 (JJJ11_06380)833527..833793+267WP_004124953.1FAD assembly factor SdhEAntitoxin
JJJ11_RS06385 (JJJ11_06385)833774..834184+411WP_024358614.1protein YgfXToxin
JJJ11_RS06390 (JJJ11_06390)834193..834714-522WP_024358613.1flavodoxin FldB-
JJJ11_RS06395 (JJJ11_06395)834836..835732+897WP_209573824.1site-specific tyrosine recombinase XerD-
JJJ11_RS06400 (JJJ11_06400)835755..836468+714WP_004134425.1bifunctional protein-disulfide isomerase/oxidoreductase DsbC-
JJJ11_RS06405 (JJJ11_06405)836474..838207+1734WP_098066860.1single-stranded-DNA-specific exonuclease RecJ-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--831068..8320961028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.97 Da        Isoelectric Point: 10.9455

>T186221 WP_024358614.1 NZ_CP067391:833774-834184 [Klebsiella grimontii]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWEIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

>T186221 NZ_CP089272:c4721803-4721489 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT186221 WP_004124953.1 NZ_CP067391:833527-833793 [Klebsiella grimontii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186221 NZ_CP089272:c4722039-4721806 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3H3L9

References