Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 56025..56761 | Replicon | plasmid pIncFIBK_IncFIIK |
| Accession | NZ_CP067373 | ||
| Organism | Klebsiella pneumoniae strain BA30371 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A8T5ZF70 |
| Locus tag | JI970_RS26000 | Protein ID | WP_004187044.1 |
| Coordinates | 56279..56761 (+) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | L7SZ29 |
| Locus tag | JI970_RS25995 | Protein ID | WP_003026799.1 |
| Coordinates | 56025..56291 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JI970_RS25980 (JI970_25970) | 51497..52891 | + | 1395 | WP_032439652.1 | cytosine permease | - |
| JI970_RS25985 (JI970_25975) | 52903..54111 | + | 1209 | WP_032439650.1 | imidazolonepropionase | - |
| JI970_RS25990 (JI970_25980) | 54104..54913 | + | 810 | WP_023329017.1 | N-formylglutamate deformylase | - |
| JI970_RS25995 (JI970_25985) | 56025..56291 | + | 267 | WP_003026799.1 | DUF1778 domain-containing protein | Antitoxin |
| JI970_RS26000 (JI970_25990) | 56279..56761 | + | 483 | WP_004187044.1 | GNAT family N-acetyltransferase | Toxin |
| JI970_RS26005 (JI970_25995) | 56968..58314 | + | 1347 | WP_077254728.1 | ISNCY family transposase | - |
| JI970_RS26010 (JI970_26000) | 58363..58761 | + | 399 | WP_032422684.1 | helix-turn-helix domain-containing protein | - |
| JI970_RS26015 (JI970_26005) | 58908..59018 | - | 111 | Protein_58 | IS3 family transposase | - |
| JI970_RS26020 (JI970_26015) | 59293..60229 | + | 937 | Protein_59 | ISNCY family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaOXA-1 / aac(6')-Ib-cr / blaCTX-M-15 / blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA14 / qnrB1 / tet(A) | - | 1..226169 | 226169 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17280.93 Da Isoelectric Point: 8.7197
>T186216 WP_004187044.1 NZ_CP067373:56279-56761 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP
Download Length: 483 bp
>T186216 NZ_CP089272:c3553450-3553295 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10147.59 Da Isoelectric Point: 4.5256
>AT186216 WP_003026799.1 NZ_CP067373:56025-56291 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
Download Length: 267 bp
>AT186216 NZ_CP089272:3553462-3553520 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|