Detailed information of TA system TA186213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4913842..4915523
• Replicon: chromosome
• Accession: NZ_CP067372
• Organism: Klebsiella pneumoniae strain BA30371

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: JI970_RS23890
• Protein ID: WP_117259258.1
• Coordinates: 4913842..4914759 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: JI970_RS23895
• Protein ID: WP_004177809.1
• Coordinates: 4914765..4915523 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JI970_RS23870 (4909148)	4909148..4910668	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
JI970_RS23875 (4910665)	4910665..4911663	+	999	WP_002885172.1	ribose ABC transporter permease	-
JI970_RS23880 (4911694)	4911694..4912635	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JI970_RS23885 (4912710)	4912710..4913717	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
JI970_RS23890 (4913842)	4913842..4914759	-	918	WP_117259258.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JI970_RS23895 (4914765)	4914765..4915523	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JI970_RS23900 (4915609)	4915609..4916337	-	729	WP_023159071.1	response regulator transcription factor	-
JI970_RS23905 (4916610)	4916610..4918757	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JI970_RS23910 (4918987)	4918987..4919673	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34644.12 Da
• Isoelectric Point: 5.2461

>T186213 WP_117259258.1 NZ_CP067372:c4914759-4913842 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PIDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T186213 NZ_CP089272:3096918-3097025 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT186213 WP_004177809.1 NZ_CP067372:c4915523-4914765 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT186213 NZ_CP089272:c3096870-3096811 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: A6TH05