Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4673440..4674132 Replicon chromosome
Accession NZ_CP067372
Organism Klebsiella pneumoniae strain BA30371

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag JI970_RS22750 Protein ID WP_071603219.1
Coordinates 4673440..4673781 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag JI970_RS22755 Protein ID WP_040189932.1
Coordinates 4673806..4674132 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI970_RS22725 (4669348) 4669348..4670802 - 1455 WP_074184809.1 serine protease -
JI970_RS22730 (4670990) 4670990..4671787 - 798 WP_038806919.1 helix-turn-helix transcriptional regulator -
JI970_RS22735 (4671888) 4671888..4672163 - 276 Protein_4459 type II toxin-antitoxin system RelE/ParE family toxin -
JI970_RS22740 (4672167) 4672167..4672415 - 249 WP_038806909.1 ribbon-helix-helix domain-containing protein -
JI970_RS22745 (4672492) 4672492..4673325 - 834 WP_038806910.1 DUF4942 domain-containing protein -
JI970_RS22750 (4673440) 4673440..4673781 - 342 WP_071603219.1 TA system toxin CbtA family protein Toxin
JI970_RS22755 (4673806) 4673806..4674132 - 327 WP_040189932.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JI970_RS22760 (4674146) 4674146..4674622 - 477 WP_038806912.1 DNA repair protein RadC -
JI970_RS22765 (4674633) 4674633..4675079 - 447 WP_038806913.1 antirestriction protein -
JI970_RS22770 (4675303) 4675303..4675992 - 690 WP_038806914.1 hypothetical protein -
JI970_RS22775 (4676311) 4676311..4676664 + 354 WP_038806915.1 hypothetical protein -
JI970_RS22780 (4676701) 4676701..4677591 - 891 WP_038806917.1 YfjP family GTPase -
JI970_RS22785 (4677689) 4677689..4678954 + 1266 WP_166686293.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4656935..4696321 39386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12762.63 Da        Isoelectric Point: 7.8846

>T186211 WP_071603219.1 NZ_CP067372:c4673781-4673440 [Klebsiella pneumoniae]
MKTIPATTQRAAKSCPSPVAFWQMPLTRLLEQHYGLTLNDTPFSDETAIQEHINAGITLVDAVNFLVEKYELVRIDRRGF
NCQEQSPYLGAVDILRARQVTGLLRQSPHPSIR

Download         Length: 342 bp

>T186211 NZ_CP089272:2677420-2677575 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12333.06 Da        Isoelectric Point: 6.9560

>AT186211 WP_040189932.1 NZ_CP067372:c4674132-4673806 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFVDAECQKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp

>AT186211 NZ_CP089272:c2677408-2677350 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References