Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 808927..809584 Replicon chromosome
Accession NZ_CP067372
Organism Klebsiella pneumoniae strain BA30371

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JI970_RS03990 Protein ID WP_002916310.1
Coordinates 809174..809584 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JI970_RS03985 Protein ID WP_002916312.1
Coordinates 808927..809193 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI970_RS03960 (804083) 804083..805516 - 1434 WP_117259198.1 6-phospho-beta-glucosidase -
JI970_RS03965 (805635) 805635..806363 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JI970_RS03970 (806413) 806413..806724 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JI970_RS03975 (806888) 806888..807547 + 660 WP_002916317.1 hemolysin III family protein -
JI970_RS03980 (807698) 807698..808681 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
JI970_RS03985 (808927) 808927..809193 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JI970_RS03990 (809174) 809174..809584 + 411 WP_002916310.1 protein YgfX Toxin
JI970_RS03995 (809591) 809591..810112 - 522 WP_004144730.1 flavodoxin FldB -
JI970_RS04000 (810213) 810213..811109 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JI970_RS04005 (811132) 811132..811845 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JI970_RS04010 (811851) 811851..813584 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T186199 WP_002916310.1 NZ_CP067372:809174-809584 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T186199 NZ_CP089271:2053-2328 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT186199 WP_002916312.1 NZ_CP067372:808927-809193 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186199 NZ_CP089271:1769-2053 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References