Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4674825..4675528 Replicon chromosome
Accession NZ_CP067370
Organism Klebsiella pneumoniae strain B9122

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag JI969_RS22700 Protein ID WP_071994632.1
Coordinates 4674825..4675166 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag JI969_RS22705 Protein ID WP_032434296.1
Coordinates 4675187..4675528 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI969_RS22690 (4671140) 4671140..4672009 + 870 WP_023317468.1 HNH endonuclease -
JI969_RS22695 (4672600) 4672600..4674633 + 2034 WP_050598589.1 hypothetical protein -
JI969_RS22700 (4674825) 4674825..4675166 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
JI969_RS22705 (4675187) 4675187..4675528 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JI969_RS22710 (4675539) 4675539..4676081 - 543 WP_032434298.1 DNA repair protein RadC -
JI969_RS22715 (4676094) 4676094..4676534 - 441 WP_032434300.1 antirestriction protein -
JI969_RS22720 (4676565) 4676565..4677386 - 822 WP_032434301.1 DUF932 domain-containing protein -
JI969_RS22725 (4677506) 4677506..4677979 - 474 WP_032434303.1 hypothetical protein -
JI969_RS22730 (4678051) 4678051..4678503 - 453 WP_032410767.1 hypothetical protein -
JI969_RS22735 (4678539) 4678539..4679255 - 717 WP_032434305.1 WYL domain-containing protein -
JI969_RS22740 (4679499) 4679499..4680373 - 875 Protein_4463 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4663122..4708795 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T186191 WP_071994632.1 NZ_CP067370:c4675166-4674825 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

>T186191 NZ_CP089270:3844242-3844628 [Escherichia coli O157:H7]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAAGCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT186191 WP_032434296.1 NZ_CP067370:c4675528-4675187 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT186191 NZ_CP089270:3844618-3844947 [Escherichia coli O157:H7]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAGGTTGA
TGCCATTGCCGTCATGGTCAAAGCCCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCACTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References