Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4242063..4242850 | Replicon | chromosome |
| Accession | NZ_CP067370 | ||
| Organism | Klebsiella pneumoniae strain B9122 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A377E3D6 |
| Locus tag | JI969_RS20660 | Protein ID | WP_001194695.1 |
| Coordinates | 4242473..4242850 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | JI969_RS20655 | Protein ID | WP_053266522.1 |
| Coordinates | 4242063..4242422 (+) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JI969_RS20610 (4237301) | 4237301..4237753 | + | 453 | WP_001020418.1 | hypothetical protein | - |
| JI969_RS20615 (4237750) | 4237750..4238202 | + | 453 | WP_000734138.1 | hypothetical protein | - |
| JI969_RS20620 (4238265) | 4238265..4238808 | + | 544 | Protein_4053 | DUF4339 domain-containing protein | - |
| JI969_RS20625 (4238868) | 4238868..4239320 | + | 453 | WP_001061894.1 | IrmA family protein | - |
| JI969_RS20630 (4239397) | 4239397..4239630 | + | 234 | WP_001614358.1 | DUF905 domain-containing protein | - |
| JI969_RS20635 (4239750) | 4239750..4240568 | + | 819 | WP_001614356.1 | DUF932 domain-containing protein | - |
| JI969_RS20640 (4240836) | 4240836..4241306 | + | 471 | WP_000131762.1 | antirestriction protein | - |
| JI969_RS20645 (4241318) | 4241318..4241797 | + | 480 | WP_000437750.1 | DNA repair protein RadC | - |
| JI969_RS20650 (4241818) | 4241818..4242039 | + | 222 | WP_044068431.1 | DUF987 domain-containing protein | - |
| JI969_RS20655 (4242063) | 4242063..4242422 | + | 360 | WP_053266522.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| JI969_RS20660 (4242473) | 4242473..4242850 | + | 378 | WP_001194695.1 | TA system toxin CbtA family protein | Toxin |
| JI969_RS20665 (4242847) | 4242847..4243338 | + | 492 | WP_000777682.1 | DUF5983 family protein | - |
| JI969_RS20670 (4243378) | 4243378..4243572 | + | 195 | WP_032155094.1 | DUF957 domain-containing protein | - |
| JI969_RS20675 (4243653) | 4243653..4244497 | + | 845 | Protein_4064 | DUF4942 domain-containing protein | - |
| JI969_RS20685 (4244841) | 4244841..4245572 | - | 732 | WP_004152034.1 | DNA polymerase III subunit epsilon | - |
| JI969_RS20690 (4245637) | 4245637..4246104 | + | 468 | WP_002889686.1 | ribonuclease HI | - |
| JI969_RS20695 (4246101) | 4246101..4246823 | - | 723 | WP_002889685.1 | class I SAM-dependent methyltransferase | - |
| JI969_RS20700 (4246856) | 4246856..4247611 | + | 756 | WP_004145833.1 | hydroxyacylglutathione hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4214216..4247611 | 33395 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14180.97 Da Isoelectric Point: 7.4209
>T186189 WP_001194695.1 NZ_CP067370:4242473-4242850 [Klebsiella pneumoniae]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
Download Length: 378 bp
>T186189 NZ_CP089270:c3380890-3380516 [Escherichia coli O157:H7]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13109.09 Da Isoelectric Point: 7.3717
>AT186189 WP_053266522.1 NZ_CP067370:4242063-4242422 [Klebsiella pneumoniae]
MSNKTPIVNHDITEPWWGLKRSITPCFGARLVQAGNCLHYLADRASITGQFSDAVLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA
MSNKTPIVNHDITEPWWGLKRSITPCFGARLVQAGNCLHYLADRASITGQFSDAVLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA
Download Length: 360 bp
>AT186189 NZ_CP089270:c3381311-3380937 [Escherichia coli O157:H7]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|