Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3970626..3971245 Replicon chromosome
Accession NZ_CP067370
Organism Klebsiella pneumoniae strain B9122

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JI969_RS19335 Protein ID WP_002892050.1
Coordinates 3971027..3971245 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag JI969_RS19330 Protein ID WP_002892066.1
Coordinates 3970626..3971000 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI969_RS19320 (3965778) 3965778..3966971 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JI969_RS19325 (3966994) 3966994..3970140 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JI969_RS19330 (3970626) 3970626..3971000 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
JI969_RS19335 (3971027) 3971027..3971245 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JI969_RS19340 (3971404) 3971404..3971970 + 567 WP_002892030.1 maltose O-acetyltransferase -
JI969_RS19345 (3971942) 3971942..3972082 - 141 WP_004147370.1 hypothetical protein -
JI969_RS19350 (3972103) 3972103..3972573 + 471 WP_002892026.1 YlaC family protein -
JI969_RS19355 (3972548) 3972548..3973999 - 1452 WP_032435563.1 PLP-dependent aminotransferase family protein -
JI969_RS19360 (3974100) 3974100..3974798 + 699 WP_032435564.1 GNAT family protein -
JI969_RS19365 (3974795) 3974795..3974935 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JI969_RS19370 (3974935) 3974935..3975198 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T186188 WP_002892050.1 NZ_CP067370:3971027-3971245 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T186188 NZ_CP089270:3120285-3120392 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT186188 WP_002892066.1 NZ_CP067370:3970626-3971000 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT186188 NZ_CP089270:c3120232-3120171 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References