Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2692084..2693672 Replicon chromosome
Accession NZ_CP067370
Organism Klebsiella pneumoniae strain B9122

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JI969_RS13275 Protein ID WP_169507579.1
Coordinates 2692084..2693406 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JI969_RS13280 Protein ID WP_004176198.1
Coordinates 2693406..2693672 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI969_RS13260 (2687140) 2687140..2689641 + 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -
JI969_RS13265 (2689629) 2689629..2690633 + 1005 WP_032435338.1 fimbrial protein -
JI969_RS13270 (2690775) 2690775..2692067 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JI969_RS13275 (2692084) 2692084..2693406 - 1323 WP_169507579.1 type II toxin-antitoxin system HipA family toxin Toxin
JI969_RS13280 (2693406) 2693406..2693672 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JI969_RS13285 (2694059) 2694059..2694385 - 327 WP_004184023.1 hydroxyisourate hydrolase -
JI969_RS13290 (2694382) 2694382..2694882 - 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JI969_RS13295 (2694860) 2694860..2696239 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
JI969_RS13300 (2696585) 2696585..2697739 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JI969_RS13305 (2697720) 2697720..2698643 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49173.50 Da        Isoelectric Point: 7.5357

>T186187 WP_169507579.1 NZ_CP067370:c2693406-2692084 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAMYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T186187 NZ_CP089270:3119749-3119856 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT186187 WP_004176198.1 NZ_CP067370:c2693672-2693406 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT186187 NZ_CP089270:c3119701-3119642 [Escherichia coli O157:H7]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References