Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 794273..794930 Replicon chromosome
Accession NZ_CP067370
Organism Klebsiella pneumoniae strain B9122

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JI969_RS03940 Protein ID WP_002916310.1
Coordinates 794520..794930 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JI969_RS03935 Protein ID WP_002916312.1
Coordinates 794273..794539 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI969_RS03910 (789481) 789481..790914 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JI969_RS03915 (791033) 791033..791761 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JI969_RS03920 (791811) 791811..792122 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JI969_RS03925 (792286) 792286..792945 + 660 WP_004174454.1 hemolysin III family protein -
JI969_RS03930 (793044) 793044..794027 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
JI969_RS03935 (794273) 794273..794539 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JI969_RS03940 (794520) 794520..794930 + 411 WP_002916310.1 protein YgfX Toxin
JI969_RS03945 (794937) 794937..795458 - 522 WP_002916308.1 flavodoxin FldB -
JI969_RS03950 (795559) 795559..796455 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JI969_RS03955 (796478) 796478..797191 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JI969_RS03960 (797197) 797197..798930 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T186177 WP_002916310.1 NZ_CP067370:794520-794930 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T186177 NZ_CP089270:372228-372503 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT186177 WP_002916312.1 NZ_CP067370:794273-794539 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186177 NZ_CP089270:372500-372859 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References