Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3408794..3409520 Replicon chromosome
Accession NZ_CP067369
Organism Salmonella bongori strain Se40

Toxin (Protein)


Gene name ykfI Uniprot ID A0A248KBV8
Locus tag JG560_RS16170 Protein ID WP_001194750.1
Coordinates 3408794..3409135 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A248KCL1
Locus tag JG560_RS16175 Protein ID WP_000380487.1
Coordinates 3409179..3409520 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG560_RS16150 3404674..3405993 + 1320 WP_001218450.1 site-specific integrase -
JG560_RS16155 3406031..3407083 - 1053 WP_000575274.1 macro domain-containing protein -
JG560_RS16160 3407097..3407744 - 648 WP_000026701.1 DUF4433 domain-containing protein -
JG560_RS16165 3407845..3408678 - 834 WP_001192753.1 DUF4942 domain-containing protein -
JG560_RS16170 3408794..3409135 - 342 WP_001194750.1 TA system toxin CbtA family protein Toxin
JG560_RS16175 3409179..3409520 - 342 WP_000380487.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JG560_RS16180 3409543..3409764 - 222 WP_000691988.1 DUF987 family protein -
JG560_RS16185 3409761..3410261 - 501 WP_001090292.1 DNA repair protein RadC -
JG560_RS16190 3410274..3411092 - 819 WP_001234407.1 DUF945 domain-containing protein -
JG560_RS16195 3411194..3411439 - 246 WP_000082136.1 DUF905 domain-containing protein -
JG560_RS16200 3411514..3412428 - 915 WP_000797249.1 hypothetical protein -
JG560_RS16205 3412493..3412696 - 204 WP_000508162.1 hypothetical protein -
JG560_RS16210 3412713..3412859 - 147 WP_023892166.1 hypothetical protein -
JG560_RS16215 3412932..3413646 - 715 Protein_3168 WYL domain-containing protein -
JG560_RS16220 3413999..3414304 - 306 WP_000227087.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3384199..3427154 42955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(2-109)

Antitoxin

Antitoxin CbeA

(11-109)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13116.01 Da        Isoelectric Point: 9.7617

>T186174 WP_001194750.1 NZ_CP067369:c3409135-3408794 [Salmonella bongori]
MQTQYNHPHRATPSQPSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRRQRYLAAH

Download         Length: 342 bp

>T186174 NZ_CP089238:c4407058-4406303 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGGAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12770.65 Da        Isoelectric Point: 9.4771

>AT186174 WP_000380487.1 NZ_CP067369:c3409520-3409179 [Salmonella bongori]
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLKTLNIVFPMFIKRMEVALRTGALNPREAR
RFTTALRGIICEADTRGSFGYVYLSLYPTVVKN

Download         Length: 342 bp

>AT186174 NZ_CP089238:c4407561-4407193 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248KBV8

Antitoxin

Source ID Structure
AlphaFold DB A0A248KCL1

References