Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3254123..3254743 Replicon chromosome
Accession NZ_CP067369
Organism Salmonella bongori strain Se40

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JG560_RS15475 Protein ID WP_001280991.1
Coordinates 3254525..3254743 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag JG560_RS15470 Protein ID WP_000344807.1
Coordinates 3254123..3254497 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG560_RS15460 3249262..3250455 + 1194 WP_001039205.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JG560_RS15465 3250478..3253627 + 3150 WP_001132513.1 multidrug efflux RND transporter permease subunit -
JG560_RS15470 3254123..3254497 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
JG560_RS15475 3254525..3254743 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
JG560_RS15480 3254922..3255473 + 552 WP_001278796.1 maltose O-acetyltransferase -
JG560_RS15485 3255591..3256061 + 471 WP_000136180.1 YlaC family protein -
JG560_RS15490 3256114..3256254 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JG560_RS15495 3256260..3256520 - 261 WP_000801419.1 type B 50S ribosomal protein L31 -
JG560_RS15500 3256725..3258275 + 1551 WP_000213124.1 EAL domain-containing protein -
JG560_RS15510 3258514..3258903 + 390 WP_000908589.1 MGMT family protein -
JG560_RS15515 3258936..3259505 - 570 WP_000779806.1 YbaY family lipoprotein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T186173 WP_001280991.1 NZ_CP067369:3254525-3254743 [Salmonella bongori]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T186173 NZ_CP089238:3461875-3462453 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGTTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGATAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT186173 WP_000344807.1 NZ_CP067369:3254123-3254497 [Salmonella bongori]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT186173 NZ_CP089238:3461232-3461786 [Pseudomonas aeruginosa]
ATGACCAAGCCTCTCCCCTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCTTGCTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCGCCACCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGATGGACGCGCGGTACGCCTGGTGGAAACCCTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4ICG


Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References