Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
| Location | 8248..8741 | Replicon | plasmid pTBH7P1 |
| Accession | NZ_CP067343 | ||
| Organism | Escherichia coli strain ECJXMCRH7 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | U9Y9W8 |
| Locus tag | JJB06_RS23845 | Protein ID | WP_001230709.1 |
| Coordinates | 8248..8502 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | U9Y4R8 |
| Locus tag | JJB06_RS23850 | Protein ID | WP_000151456.1 |
| Coordinates | 8499..8741 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJB06_RS23810 (JJB06_23700) | 3553..3837 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| JJB06_RS23815 (JJB06_23705) | 3911..4576 | - | 666 | WP_000532149.1 | division plane positioning ATPase MipZ | - |
| JJB06_RS23820 (JJB06_23710) | 4766..5074 | - | 309 | WP_257713994.1 | CopG family transcriptional regulator | - |
| JJB06_RS23825 (JJB06_23715) | 5148..5771 | - | 624 | WP_219360914.1 | division plane positioning ATPase MipZ | - |
| JJB06_RS23830 (JJB06_23720) | 6360..6689 | + | 330 | WP_001542022.1 | hypothetical protein | - |
| JJB06_RS23835 (JJB06_23725) | 7090..7605 | + | 516 | WP_001025393.1 | J domain-containing protein | - |
| JJB06_RS23840 (JJB06_23730) | 7709..8251 | + | 543 | WP_001083904.1 | hypothetical protein | - |
| JJB06_RS23845 (JJB06_23735) | 8248..8502 | + | 255 | WP_001230709.1 | hypothetical protein | Toxin |
| JJB06_RS23850 (JJB06_23740) | 8499..8741 | + | 243 | WP_000151456.1 | hypothetical protein | Antitoxin |
| JJB06_RS23855 (JJB06_23745) | 9312..9605 | + | 294 | WP_000673428.1 | hypothetical protein | - |
| JJB06_RS23860 (JJB06_23750) | 10094..10342 | + | 249 | WP_000513532.1 | type II toxin-antitoxin system HicA family toxin | - |
| JJB06_RS23865 (JJB06_23755) | 10339..10686 | + | 348 | WP_000681609.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| JJB06_RS25105 | 10774..11217 | - | 444 | WP_023223351.1 | hypothetical protein | - |
| JJB06_RS23875 (JJB06_23765) | 11458..11757 | + | 300 | WP_034169410.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| JJB06_RS23880 (JJB06_23770) | 12017..12343 | - | 327 | WP_000206697.1 | hypothetical protein | - |
| JJB06_RS23885 (JJB06_23775) | 12345..12668 | - | 324 | WP_223666488.1 | hypothetical protein | - |
| JJB06_RS25110 | 12645..12785 | - | 141 | Protein_22 | hypothetical protein | - |
| JJB06_RS23890 (JJB06_23780) | 12805..13512 | - | 708 | WP_000108794.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61586 | 61586 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9942.47 Da Isoelectric Point: 10.1206
>T186150 WP_001230709.1 NZ_CP067343:8248-8502 [Escherichia coli]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
Download Length: 255 bp
>T186150 NZ_CP089234:797809-798219 [Klebsiella sp. KPN54798]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9136.45 Da Isoelectric Point: 7.2775
>AT186150 WP_000151456.1 NZ_CP067343:8499-8741 [Escherichia coli]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
Download Length: 243 bp
>AT186150 NZ_CP089234:797562-797828 [Klebsiella sp. KPN54798]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G9H8F0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G9GNF5 |