Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4360599..4361397 Replicon chromosome
Accession NZ_CP067342
Organism Escherichia coli strain ECJXMCRH7

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag JJB06_RS21480 Protein ID WP_000854735.1
Coordinates 4361020..4361397 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag JJB06_RS21475 Protein ID WP_032153712.1
Coordinates 4360599..4360973 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB06_RS21440 (4356332) 4356332..4357216 + 885 WP_024166630.1 50S ribosome-binding GTPase -
JJB06_RS21445 (4357335) 4357335..4358012 + 678 WP_023155728.1 hypothetical protein -
JJB06_RS21450 (4358042) 4358042..4358251 + 210 WP_023155727.1 DUF905 family protein -
JJB06_RS21455 (4358342) 4358342..4359160 + 819 WP_001234693.1 DUF932 domain-containing protein -
JJB06_RS21460 (4359252) 4359252..4359737 + 486 WP_032153711.1 antirestriction protein -
JJB06_RS21465 (4359753) 4359753..4360229 + 477 WP_001186715.1 RadC family protein -
JJB06_RS21470 (4360298) 4360298..4360519 + 222 WP_000692345.1 DUF987 domain-containing protein -
JJB06_RS21475 (4360599) 4360599..4360973 + 375 WP_032153712.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JJB06_RS21480 (4361020) 4361020..4361397 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
JJB06_RS21485 (4361394) 4361394..4361885 + 492 WP_023155722.1 DUF5983 family protein -
JJB06_RS21490 (4361897) 4361897..4362094 + 198 WP_000839265.1 DUF957 domain-containing protein -
JJB06_RS21495 (4362179) 4362179..4363045 + 867 WP_032153714.1 DUF4942 domain-containing protein -
JJB06_RS21500 (4363117) 4363117..4363380 + 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
JJB06_RS21505 (4363377) 4363377..4363703 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
JJB06_RS21510 (4364586) 4364586..4366124 + 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island blaCTX-M-14 - 4307486..4373937 66451


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T186148 WP_000854735.1 NZ_CP067342:4361020-4361397 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T186148 NZ_CP089234:327823-328191 [Klebsiella sp. KPN54798]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACTGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT186148 WP_032153712.1 NZ_CP067342:4360599-4360973 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT186148 NZ_CP089234:327605-327826 [Klebsiella sp. KPN54798]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References