Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 982205..982859 Replicon chromosome
Accession NZ_CP067342
Organism Escherichia coli strain ECJXMCRH7

Toxin (Protein)


Gene name cptA Uniprot ID A0A140N853
Locus tag JJB06_RS04810 Protein ID WP_000244783.1
Coordinates 982452..982859 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JJB06_RS04805 Protein ID WP_000354046.1
Coordinates 982205..982471 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB06_RS04780 (977374) 977374..978117 + 744 WP_000951948.1 SDR family oxidoreductase -
JJB06_RS04785 (978174) 978174..979607 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
JJB06_RS04790 (979652) 979652..979963 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
JJB06_RS04795 (980127) 980127..980786 + 660 WP_000250274.1 hemolysin III family protein -
JJB06_RS04800 (980982) 980982..981962 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
JJB06_RS04805 (982205) 982205..982471 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JJB06_RS04810 (982452) 982452..982859 + 408 WP_000244783.1 protein YgfX Toxin
JJB06_RS04815 (982899) 982899..983420 - 522 WP_001055874.1 flavodoxin FldB -
JJB06_RS04820 (983532) 983532..984428 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JJB06_RS04825 (984453) 984453..985163 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JJB06_RS04830 (985169) 985169..986902 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15962.85 Da        Isoelectric Point: 11.2669

>T186130 WP_000244783.1 NZ_CP067342:982452-982859 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEISLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T186130 NZ_CP089224:c3019501-3019091 [Mycobacterium ostraviense]
GTGATTTACCTGGACACGTCGGCTCTGACCAAATTGCTCATCGCTGAACCGGAGACGGCCGATCTGCGCAGCTGGCTGAC
TTCGCAACGAGAACAGGGCGAATTCGCGGCGACGAGCGCGCTCGGACGGGTCGAGTTGATGAGAGTCGTTGCCCGGTACG
GGGACCCGGCCCACGTCGAACGTGCACGCTACCTTCTGGACGGGCTCGACATTCTTCCGCTCACCGCGCCGGTGATGAAT
CTCGCCGAAACGATCGGCCCGGCCACCCTGCGCTCGCTCGACGCGATTCACCTCGCAGCGGCCACGCAGATCAAGCGGGA
GCTGAGCGCGTTTGTGACCTATGACCATCGTTTGTTGGCCGGCTGCCTCGAGGTCGGGCTGGTGACCGCATCGCCCGGCG
CAGTCCGCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT186130 WP_000354046.1 NZ_CP067342:982205-982471 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186130 NZ_CP089224:c3019776-3019498 [Mycobacterium ostraviense]
GTGGAAGTGATTGGCGTCCGAGAGCTCCGGCAGCACGCATCGCGGTATCTCGCCCGGGTTGAAGCTGGCGAGGAACTCGG
CATCACCAATAACGGGCGGCTCGTCGCCCGACTTGTTCCGGTGCGGGCGGCAGAGCGTTCTCGCGAAGCCCTGATCGAAT
CAGGCGCCGTGATTGCGGCCCCACGCCCGCAGAACCTTTTCGAGGTGACAGCAACACCGGCGCCGGATCGCAAGCGCACT
CTCTCCGATGTTCTCGACGAGATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A140N853

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References