Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 716344..717185 Replicon chromosome
Accession NZ_CP067342
Organism Escherichia coli strain ECJXMCRH7

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag JJB06_RS03465 Protein ID WP_000854822.1
Coordinates 716802..717185 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0CWL2
Locus tag JJB06_RS03460 Protein ID WP_053271974.1
Coordinates 716344..716712 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB06_RS03440 (714089) 714089..714907 + 819 WP_001234702.1 DUF932 domain-containing protein -
JJB06_RS03445 (714998) 714998..715483 + 486 WP_000214317.1 antirestriction protein -
JJB06_RS03450 (715498) 715498..715974 + 477 WP_001186747.1 RadC family protein -
JJB06_RS03455 (716043) 716043..716264 + 222 WP_000692312.1 DUF987 domain-containing protein -
JJB06_RS03460 (716344) 716344..716712 + 369 WP_053271974.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JJB06_RS03465 (716802) 716802..717185 + 384 WP_000854822.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
JJB06_RS03470 (717176) 717176..717664 + 489 WP_001177592.1 DUF5983 family protein -
JJB06_RS03475 (717676) 717676..717873 + 198 WP_000839263.1 DUF957 domain-containing protein -
JJB06_RS03480 (717970) 717970..718815 + 846 WP_040234917.1 DUF4942 domain-containing protein -
JJB06_RS03490 (719114) 719114..719620 + 507 WP_000228937.1 G/U mismatch-specific DNA glycosylase -
JJB06_RS03495 (719699) 719699..721540 - 1842 WP_000437375.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T186127 WP_000854822.1 NZ_CP067342:716802-717185 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

>T186127 NZ_CP089224:c1464737-1463856 [Mycobacterium ostraviense]
GTGACCAAGCCCTATTCTTCGCCGCCGACGAACTTGCGCTCGCTGCGAGATCGACTCACCCAGGCAGCGCAGCGGCAAGG
TGTCGTGTTCGGTCGACTACAGCGGCACATCGCGATGATCGTCGTCGCACAGTTCGCAGCCATGCTCACCGACGACAGCG
GTGCTCCGCTGCTCTTGGTTAAAGGCGGATCGTCGCTGGAATTGCGCCGAGGGATCCCCGATTCACGGACCTCCAAAGAC
TTCGACACGGTCGCACGCCGCGACATCGCAACGGTCCATGAGCAGCTGGCCGATGCGGGGGAGACTGGGTGGGAGGGGTT
CACAGCTACCTTCACCGTTCCCGAAGAGATCGACGTCCCGGGCATGCCGGTCAAGCCTCGCCGATTCACCGCCAAGCTGA
GTTACCGTGGCCAGCCTTTCGTATCTGTTCCCATCGAGGTCTCCAACGTCGAAGCCGGCAATGCCGACCAGTTCGACACT
CTTACCTCGGATGCTCTCGGCCTTGTCGGCGTTCCCGCAGCGGTCGCGGTGCCGTGTATGACCATTCCCTGGCAGATCGC
GCAGAAGCTCCACGCGGTGACCGCCGTGCTCGAAGCGCCGAGAGTGAACGATCGCGCTCACGACTTGGTGGACTTGCAGC
TTCTCGAAGGACTGCTGCCCGATAGCGATCTCTTGCCAACGCGCAGCGCGTGCATCGCGGTATTTGAAGCACGCGCTCAG
CATCCGTGGCCACCCCAAGTCACCGCGCTGCCGCATTGGCCGCCAATCTACTCGGGGGCATTGGAGGGGCTGGATCACCT
TGAACTTGCCGCCACAGTTGAGGAGGCAGTCAAGGCGGTGCGACGATTTGTCGAGCGGATAGATGTGGCGACAGAAACGT
AA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13679.41 Da        Isoelectric Point: 6.4758

>AT186127 WP_053271974.1 NZ_CP067342:716344-716712 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT186127 NZ_CP089224:c1465318-1464734 [Mycobacterium ostraviense]
ATGACTATCTGGGATCGGCTTGTTGAACTTGCCGCCGAGCAACATGGCTACGTCACGACTCGTGACGCGCGGGATATCGG
TGTGGACCCCGTGCAGCTCCGTCTTCTGGCCGCACGCGGGCGTCTTGAGCGTGCTGGTCGTGGTGTGTACCGGGTGCCCG
TCTTGCCGCGCGGTGAGCACGACGATCTCGCAGCAGCGGTCTCGTGGACTTTGGGCCGTGGTGTCATCTCGCATGAGTCG
GCCTTGGGGCTTCACGCCCTCTCGGATGTCAACCCTTCGCGGATCCATCTCACGGTCCCACGCGAGAACCATCCGCGCGC
AGCGGGGGGCGAGTTGTACCGACTTCACCGCCGCGACCTCCAGGCAACCGACATCACCTTGGTCGACGGCATACCCGTCA
CGACGGCTGTGCGCACCATCAGAGACTGCCTGAAGGCGGGCACTGATCCTTATCAGCTTCGGGTGGCGATCGAGCGAGCC
GAAGCCGAGGGCACGCTACGTCGTGCGCCGGCAGCTGAGCTACGCGCTGCGCTCGATCAACCCGCCGCCGGAGTACGCGC
TCGGACGAAGCGAGCATCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CWL2

References