Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 2926980..2927502 Replicon chromosome
Accession NZ_CP067336
Organism Actinomyces sp. HMT897

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JJJ15_RS11370 Protein ID WP_200510805.1
Coordinates 2927239..2927502 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JJJ15_RS11365 Protein ID WP_200510804.1
Coordinates 2926980..2927237 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJJ15_RS11345 2922711..2923943 + 1233 WP_200510802.1 hypothetical protein -
JJJ15_RS11350 2924176..2924388 + 213 WP_106108738.1 50S ribosomal protein L31 -
JJJ15_RS11355 2924506..2925606 + 1101 WP_200510803.1 peptide chain release factor 1 -
JJJ15_RS11360 2925917..2926759 + 843 WP_200512059.1 peptide chain release factor N(5)-glutamine methyltransferase -
JJJ15_RS11365 2926980..2927237 + 258 WP_200510804.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JJJ15_RS11370 2927239..2927502 + 264 WP_200510805.1 Txe/YoeB family addiction module toxin Toxin
JJJ15_RS11375 2927576..2928289 + 714 WP_200510806.1 DNA alkylation repair protein -
JJJ15_RS11380 2928529..2928687 + 159 WP_200510807.1 hypothetical protein -
JJJ15_RS11385 2928691..2930943 + 2253 WP_200510808.1 AAA family ATPase -
JJJ15_RS11390 2931035..2931403 + 369 WP_200510809.1 hypothetical protein -
JJJ15_RS11395 2931422..2932171 + 750 WP_200510810.1 NAD(P)H-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-69)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10414.66 Da        Isoelectric Point: 7.1155

>T186124 WP_200510805.1 NZ_CP067336:2927239-2927502 [Actinomyces sp. HMT897]
VAIAWDDSAWEDYLWWQAHDRKVRRRINLLLRDIQCSGHEGIGKPEPLRYQLTGHWSRRITDEHRLVYRIDDGGDIHIVA
CRHHYGD

Download         Length: 264 bp

>T186124 NZ_CP089223:c3375239-3374868 [Mycobacterium avium subsp. avium]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAATGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTCGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9488.63 Da        Isoelectric Point: 4.6239

>AT186124 WP_200510804.1 NZ_CP067336:2926980-2927237 [Actinomyces sp. HMT897]
VKIMSYTESRAHYAEVLDSVIDDCEEVVITRAGRAPAVIVSLAEYQSLKETDYLLRNPANAKRLLEAVAHSRAGQDTYHD
PIEVD

Download         Length: 258 bp

>AT186124 NZ_CP089223:c3375432-3375226 [Mycobacterium avium subsp. avium]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References