Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/MazF(toxin)
Location 2314309..2314877 Replicon chromosome
Accession NZ_CP067336
Organism Actinomyces sp. HMT897

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag JJJ15_RS09055 Protein ID WP_200512015.1
Coordinates 2314309..2314632 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID -
Locus tag JJJ15_RS09060 Protein ID WP_200510520.1
Coordinates 2314644..2314877 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJJ15_RS09035 2309588..2311954 + 2367 WP_200510517.1 phosphoribosylformylglycinamidine synthase subunit PurL -
JJJ15_RS09040 2312083..2312424 + 342 WP_200512014.1 nuclear transport factor 2 family protein -
JJJ15_RS09045 2312563..2312916 - 354 WP_200510518.1 MerR family transcriptional regulator -
JJJ15_RS09050 2313053..2314225 + 1173 WP_200510519.1 MFS transporter -
JJJ15_RS09055 2314309..2314632 - 324 WP_200512015.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JJJ15_RS09060 2314644..2314877 - 234 WP_200510520.1 ribbon-helix-helix domain-containing protein Antitoxin
JJJ15_RS09065 2315188..2315364 - 177 WP_200510521.1 hypothetical protein -
JJJ15_RS09070 2317606..2318595 + 990 WP_200510522.1 DUF3152 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11603.27 Da        Isoelectric Point: 4.3696

>T186123 WP_200512015.1 NZ_CP067336:c2314632-2314309 [Actinomyces sp. HMT897]
IWWADFSEPVGSEPEYLRPALIISSDRFNQSHISTVIVSAITSNMRLAAAPGNIELERGEGGVPKDCVVNVSQTLVVDRS
RLVDPIGTLPAHLLVQVDDGLWLVLGL

Download         Length: 324 bp

>T186123 NZ_CP089223:c2501795-2501391 [Mycobacterium avium subsp. avium]
ATGACTGCAAGGCCGGCCGGGGTGCTCGACACCTCGGTGTTCATCGCGTCCGAAAGCGGACGGCACCTGGACGAGGCGCG
AATCCCCGACGAGGTAGCCACCACCGTCATCACCCTTGCCGAACTTCACGCCGGCGTATTAGCCGCGACGACGTCCGACG
TTCGGGCGCAACGCCTCGCAACGCTGGAATCGATAGCGGATATGGAAATGTTGCCAGTCGACGACGACGCGGCCCGCATG
TGGGCAAGGTTGCGGATCCACCTAGCCGAGGCTGGACGGCGGATGCGGGCTAATGATCTGTGGATCGCGGGGATCGCGGC
ATCGCGGGGACTGCCCGTTGTCACCCAGGATGACGACTTCGCCGCACTCGACGGCGCGGCGAACCTGGCGATTATTCGGG
TTTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8413.48 Da        Isoelectric Point: 4.9681

>AT186123 WP_200510520.1 NZ_CP067336:c2314877-2314644 [Actinomyces sp. HMT897]
VKTAISVPDPLFHKAEQLARRLGWSRSQLYAQAVRELIARQGDDPVTAALNDLADEMGAETPPSTGRALIQAGAWEW

Download         Length: 234 bp

>AT186123 NZ_CP089223:c2502052-2501792 [Mycobacterium avium subsp. avium]
ATGTCTGAAGTGGCGTCTCGCGAGCTGCGCAACGATACGGCGGGGGTACTGCGGCGCGTGCGGGAAGGGGAGGACGTCAC
CATCACCGTCAACGGCCGAGCCGTCGCGATGCTGACCGCGCTGGGGCCGCAGCGACGGCGGTGGCTGAGCAAGGCGGAGT
TGCTGTCGCGCTTGCGCCGCGCGCAAGCCGATCCCGGGCTACGCCAAGACCTCGCAACCCTTGCAGGCGACACAACTGAG
GACCTCGGTCCGATCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References