Detailed information of TA system TA186121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 214046..214576
• Replicon: chromosome
• Accession: NZ_CP067336
• Organism: Actinomyces sp. HMT897

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JJJ15_RS00870
• Protein ID: WP_210338794.1
• Coordinates: 214046..214288 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JJJ15_RS00875
• Protein ID: WP_200511122.1
• Coordinates: 214340..214576 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJJ15_RS00860	210102..211670	-	1569	WP_200511862.1	acyl-CoA carboxylase subunit beta	-
JJJ15_RS00865	211736..213589	-	1854	WP_200511121.1	ATP-grasp domain-containing protein	-
JJJ15_RS00870	214046..214288	-	243	WP_210338794.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
JJJ15_RS00875	214340..214576	-	237	WP_200511122.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JJJ15_RS00880	214890..215777	+	888	WP_210338795.1	hypothetical protein	-
JJJ15_RS00885	215952..216653	-	702	WP_106109122.1	ribulose-phosphate 3-epimerase	-
JJJ15_RS00890	217036..218691	-	1656	WP_200511124.1	rRNA small subunit methyltransferase B	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-77)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-59)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9100.28 Da
• Isoelectric Point: 10.4437

>T186121 WP_210338794.1 NZ_CP067336:c214288-214046 [Actinomyces sp. HMT897]
VKRRHASTRLLQEVMDLILDDTTSSRSELRRRHRAHRLKGEWRGASECHVASAGDWLLVWKTESGLAVLPRTGTHEESVG

Nucleotide

• Length: 243 bp

>T186121 NZ_CP089222:5173855-5174316 [Mycobacterium intracellulare subsp. intracellulare]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACCATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAGGGCTCGGTCGTCGAGTCGA
TTGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGTTTCGA
CGTGCACCTCGGTGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCCGCCGCACTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGACGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9005.01 Da
• Isoelectric Point: 4.5463

>AT186121 WP_200511122.1 NZ_CP067336:c214576-214340 [Actinomyces sp. HMT897]
VDEETRREAARIAEDLGFDLPSVTRAFYRQIVRENRLPLAYLAPNTESREALREADEIITRGTSRFTSREECYAELGI

Nucleotide

• Length: 237 bp

>AT186121 NZ_CP089222:5173663-5173851 [Mycobacterium intracellulare subsp. intracellulare]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTCGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCAGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGCGAAGAAGGCGGCGGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA