Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 250223..250773 | Replicon | plasmid p027_SK3a |
| Accession | NZ_CP067312 | ||
| Organism | Escherichia coli strain 027_SK3 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | S1EZ93 |
| Locus tag | JJB21_RS23605 | Protein ID | WP_007372286.1 |
| Coordinates | 250465..250773 (+) | Length | 103 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | S1FMC3 |
| Locus tag | JJB21_RS23600 | Protein ID | WP_007372285.1 |
| Coordinates | 250223..250462 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJB21_RS23555 (JJB21_23545) | 245230..245625 | + | 396 | WP_024196081.1 | hypothetical protein | - |
| JJB21_RS23560 (JJB21_23550) | 245807..245998 | + | 192 | WP_016241560.1 | hypothetical protein | - |
| JJB21_RS23565 (JJB21_23555) | 246129..246824 | + | 696 | WP_007372278.1 | hypothetical protein | - |
| JJB21_RS23570 (JJB21_23560) | 246847..247044 | + | 198 | WP_032155220.1 | Lar family restriction alleviation protein | - |
| JJB21_RS23575 (JJB21_23565) | 247097..247555 | + | 459 | WP_008786599.1 | hypothetical protein | - |
| JJB21_RS23580 (JJB21_23570) | 247703..247843 | + | 141 | WP_007372281.1 | hypothetical protein | - |
| JJB21_RS23585 (JJB21_23575) | 247859..248491 | + | 633 | WP_007372282.1 | hypothetical protein | - |
| JJB21_RS23590 (JJB21_23580) | 248949..249623 | + | 675 | WP_008786597.1 | hypothetical protein | - |
| JJB21_RS23595 (JJB21_23585) | 249620..250084 | + | 465 | WP_008786596.1 | hypothetical protein | - |
| JJB21_RS23600 (JJB21_23590) | 250223..250462 | + | 240 | WP_007372285.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| JJB21_RS23605 (JJB21_23595) | 250465..250773 | + | 309 | WP_007372286.1 | CcdB family protein | Toxin |
| JJB21_RS23610 (JJB21_23600) | 250794..250952 | + | 159 | WP_016241558.1 | hypothetical protein | - |
| JJB21_RS23615 (JJB21_23605) | 251107..251661 | + | 555 | WP_007372288.1 | hypothetical protein | - |
| JJB21_RS23620 (JJB21_23610) | 251731..252348 | + | 618 | WP_007372289.1 | hypothetical protein | - |
| JJB21_RS23625 (JJB21_23615) | 252431..252901 | + | 471 | WP_007372290.1 | HAD domain-containing protein | - |
| JJB21_RS23630 (JJB21_23620) | 253203..253490 | + | 288 | WP_016241556.1 | hypothetical protein | - |
| JJB21_RS23635 (JJB21_23625) | 253501..253899 | + | 399 | WP_007372292.1 | hypothetical protein | - |
| JJB21_RS23640 (JJB21_23630) | 253983..254309 | + | 327 | WP_007372293.1 | hypothetical protein | - |
| JJB21_RS23645 (JJB21_23635) | 254672..255010 | - | 339 | WP_007372294.1 | hypothetical protein | - |
| JJB21_RS23650 (JJB21_23640) | 255248..255691 | + | 444 | WP_007372295.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..293362 | 293362 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11351.17 Da Isoelectric Point: 8.5044
>T186119 WP_007372286.1 NZ_CP067312:250465-250773 [Escherichia coli]
MQYTVYRNPGNSQAYPYLLDIQSDIIGELNTRLVIPLHRLKKGASAPVARLTPVIQVEGNDVILMTHEMASVRVKQLGQA
VMDASPFRHTIKSAVDFLLDGF
MQYTVYRNPGNSQAYPYLLDIQSDIIGELNTRLVIPLHRLKKGASAPVARLTPVIQVEGNDVILMTHEMASVRVKQLGQA
VMDASPFRHTIKSAVDFLLDGF
Download Length: 309 bp
>T186119 NZ_CP089222:1147027-1147434 [Mycobacterium intracellulare subsp. intracellulare]
ATGAGCAACCCGCAGGTGGCCGGAGTGCTCGACACTTCGGTGTTCATCGCGACCGAAAGTGGTCGGCCTCTCGACGCGGC
GCTGATCCCTGATCAAGTTGGCACTACGGTTGTTACCCTCGCGGAACTGCACGTTGGTGTGTTGGCCGCGTCGACTTCCG
ATATTAGAGCGCAGCGCCTGGCGACATTGGAATCCATTGCGGATATCGAAGCGCTGCCGGTCGATGACGATGCGGCCCGG
ATGTGGGCCCGGCTGCGGATCCATCTCGCCGAGACCGGTCAACGCGTCCGGATCAACGATCTGTGGATCGCGGCCATCGC
GGCGTCCCGAGGGCTGCCTGTTGTCACGCAGGACGATGACTTTGCCGTCTTGGATGGTGCGGCCAATTTAACCGTTATCC
GCGTCTGA
ATGAGCAACCCGCAGGTGGCCGGAGTGCTCGACACTTCGGTGTTCATCGCGACCGAAAGTGGTCGGCCTCTCGACGCGGC
GCTGATCCCTGATCAAGTTGGCACTACGGTTGTTACCCTCGCGGAACTGCACGTTGGTGTGTTGGCCGCGTCGACTTCCG
ATATTAGAGCGCAGCGCCTGGCGACATTGGAATCCATTGCGGATATCGAAGCGCTGCCGGTCGATGACGATGCGGCCCGG
ATGTGGGCCCGGCTGCGGATCCATCTCGCCGAGACCGGTCAACGCGTCCGGATCAACGATCTGTGGATCGCGGCCATCGC
GGCGTCCCGAGGGCTGCCTGTTGTCACGCAGGACGATGACTTTGCCGTCTTGGATGGTGCGGCCAATTTAACCGTTATCC
GCGTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8784.97 Da Isoelectric Point: 8.6387
>AT186119 WP_007372285.1 NZ_CP067312:250223-250462 [Escherichia coli]
MQATAARQKKTVSVTLEPMLVQQAKDAGINLSATLAEALQSKLKASAAEEWKRQNRAGIQELNRITEEHGLLSDEYRTF
MQATAARQKKTVSVTLEPMLVQQAKDAGINLSATLAEALQSKLKASAAEEWKRQNRAGIQELNRITEEHGLLSDEYRTF
Download Length: 240 bp
>AT186119 NZ_CP089222:1146770-1147030 [Mycobacterium intracellulare subsp. intracellulare]
ATGTCTGAAGTGGCATCTCGTGAGCTGCGCAACGATACGGCTGGGGTGCTGCGGCGGGTTCGGGATGGAGAGGACGTCAC
CATCACTGTCAGTGGCCGACCGGTCGCAGTTCTTACCGCAGTTGTCCCTCAGCGCAGGCGTTGGCTGAGCAAGACGGAGT
TGCTGTCGCGCTTGCCCCGCGTTCAAGCGGATCCGGGATTACGCGAGGACCTTCACGCACTCGCCGGCGACACTACCGAG
GAGCTGGGCCCGATCCGATGA
ATGTCTGAAGTGGCATCTCGTGAGCTGCGCAACGATACGGCTGGGGTGCTGCGGCGGGTTCGGGATGGAGAGGACGTCAC
CATCACTGTCAGTGGCCGACCGGTCGCAGTTCTTACCGCAGTTGTCCCTCAGCGCAGGCGTTGGCTGAGCAAGACGGAGT
TGCTGTCGCGCTTGCCCCGCGTTCAAGCGGATCCGGGATTACGCGAGGACCTTCACGCACTCGCCGGCGACACTACCGAG
GAGCTGGGCCCGATCCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|