Detailed information of TA system TA186108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 724269..724907
• Replicon: chromosome
• Accession: NZ_CP067311
• Organism: Escherichia coli strain 027_SK3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S1F9G9
• Locus tag: JJB21_RS03665
• Protein ID: WP_000813794.1
• Coordinates: 724731..724907 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: JJB21_RS03660
• Protein ID: WP_001270286.1
• Coordinates: 724269..724685 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJB21_RS03640 (719421)	719421..720362	-	942	WP_001251304.1	ABC transporter permease	-
JJB21_RS03645 (720363)	720363..721376	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
JJB21_RS03650 (721394)	721394..722539	-	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
JJB21_RS03655 (722784)	722784..724190	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
JJB21_RS03660 (724269)	724269..724685	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
JJB21_RS03665 (724731)	724731..724907	-	177	WP_000813794.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
JJB21_RS03670 (725129)	725129..725359	+	231	WP_000494244.1	YncJ family protein	-
JJB21_RS03675 (725451)	725451..727412	-	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
JJB21_RS03680 (727485)	727485..728021	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
JJB21_RS03685 (728074)	728074..729288	+	1215	WP_071607158.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6749.83 Da
• Isoelectric Point: 11.2298

>T186108 WP_000813794.1 NZ_CP067311:c724907-724731 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T186108 NZ_CP089218:c4618352-4617699 [Mycobacterium kansasii]
GTGAGCACCACCATCGGACCCAACGAGCACGGCATCGAGGAAATTTTTCAAGCCCTCGACACGCTTGAAGCGTGGCGCGC
TGCGCATGCCCGTCCCCTTCAGGCCGCGACCATGGGCCTGCGTTCGCGGGTAGCCACGATGGGCTGCTCGCAGATCGAGG
TATCACAGCGGCTAGAACGCATTCCGACGATCATCGACAAACTGCGTCGCGAACCGGGCATGAACCTCGGGCGGATGGCA
GACATCGGTGGCTGTCGAGCCGTTTTGCGCGACGTCGACGAGGTGCGGCGCGTACAGTCCCGCTACGCCGGCGCCGCCGT
TACCGTCAGAACCAGGGATTACGTTGAGCAGCCAAAGTCGGACGGCTATCGCGCCGTACATGTGATCGTCCGCTACCACG
GTCGCCTGATCGAGGTTCAGCTGCGAACGCAGGTGCAACACGAATGGGCCTATACGGTGGAGAGCGTTACGTCGCGCTTC
GGGCTCGACATCAAGGCCGGTGGCGGGCCGCGGCCGGTGCATGACTGGTTCGTAGCGGTGTCAGAAGCGATGGCGCTGGA
AGAATACGGTGAGCCGGTAGCGCCGGAGCTGTTGCGGCGTGTAGATACACTGAGGGCAGCCGCCCAGCCTTACCTGCAAG
GAGTACGACGATGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT186108 WP_001270286.1 NZ_CP067311:c724685-724269 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT186108 NZ_CP089218:c4617702-4617448 [Mycobacterium kansasii]
ATGACTGCATCGCTGAATCACTTCTTGCTCGTCTTCGACCACAGCCGGGCCGAGCTGGTGGACCTGAAGAACTTCGGCAC
CGACGCGAAGAGTGCGATGGCGGAATACGCCCGCTTAGAGCGAGAGCACATGGGCAAGTCGGACGCGATTGAGATCGTGC
TGATCGGTTCCGATTCACTGGAAACGGTAAAGGTCACGCACGCCAACTACTTCGATGGCACCGTTGCGGTCTCAAAGTAT
TTTGCTGGCATCTAA

Structures

Toxin

• PDB: 6HPB