Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4669159..4669959 Replicon chromosome
Accession NZ_CP067307
Organism Escherichia coli strain ABW_A19

Toxin (Protein)


Gene name ataT Uniprot ID A0A891SNC1
Locus tag JJB22_RS22135 Protein ID WP_000342448.1
Coordinates 4669159..4669686 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID U9Y285
Locus tag JJB22_RS22140 Protein ID WP_001277109.1
Coordinates 4669693..4669959 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB22_RS22110 (4664234) 4664234..4665001 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
JJB22_RS22115 (4664998) 4664998..4666275 - 1278 WP_042063469.1 branched chain amino acid ABC transporter permease LivM -
JJB22_RS22120 (4666272) 4666272..4667198 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
JJB22_RS22125 (4667246) 4667246..4668355 - 1110 WP_021578039.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
JJB22_RS22130 (4668779) 4668779..4669162 + 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
JJB22_RS22135 (4669159) 4669159..4669686 - 528 WP_000342448.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
JJB22_RS22140 (4669693) 4669693..4669959 - 267 WP_001277109.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
JJB22_RS22145 (4670109) 4670109..4671212 - 1104 WP_001022009.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
JJB22_RS22150 (4671483) 4671483..4672337 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
JJB22_RS22155 (4672582) 4672582..4673640 - 1059 WP_001042006.1 permease-like cell division protein FtsX -
JJB22_RS22160 (4673633) 4673633..4674301 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(88-150)

Antitoxin

(2-86)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19692.68 Da        Isoelectric Point: 7.3232

>T186094 WP_000342448.1 NZ_CP067307:c4669686-4669159 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYKSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

>T186094 NZ_CP089216:3457810-3458220 [Mycobacterium kansasii]
GTGATTTATCTGGACACGTCGGCTCTGACTAAGTTGCTCATCGCTGAACCGGAGACGGACGAACTGCGCAACTGGCTTAC
CGTGCACACAGACCAGGGCGAATTCGCGGCGACGAGCGCGCTCAGCCGGGTCGAGTTGATGAGAGTTGTTGCGCGGCAAG
GGGAATCCGGCCAAGCTGAACGCGCGCGTTACCTACTGGACGGGCTCGACATTCTCCCGCTCACCGCGCCGGTGATCAAT
CTCGCCGAAACGATCGGCCCGGCTACCCTGCGCACGCTCGACGCGATTCACCTCGCAGCGGCAACGCAGATCAAGCGGGA
GCTGACCGCGTTTGTGACCTATGACCACCGTTTGTTGGCCGGCTGCCTCGAGGTCGGGCTGGTGACCGCATCGCCCGGCG
CAGTCCGCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.37 Da        Isoelectric Point: 10.0863

>AT186094 WP_001277109.1 NZ_CP067307:c4669959-4669693 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AVKRLQGM

Download         Length: 267 bp

>AT186094 NZ_CP089216:3457535-3457813 [Mycobacterium kansasii]
GTGGAAGCGATTGGGGTCCGAGAGCTGCGGCAGCATGCATCGCGGTATCTCGCCCGGGTTGAAGCCGGCGAGGAACTCGG
CATCACCAACAACGGGCGGCTCGTCGCCCGGCTCGTGCCGGTTCAGGCGGCAGAGCGTTCTCGCGAAGCCCTGATCGAAT
CAGGCACCCTGATTCCGGCCCCATGCCCGCAGAACCTTCTCGACGTGACGGCGACACCGGCGCCAGACCGCAAGCGCACT
CTCTCCGATGTTCTCGACGAGATGCGCGACGAGCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6GTS


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LUN0

References