Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4119957..4120789 | Replicon | chromosome |
| Accession | NZ_CP067307 | ||
| Organism | Escherichia coli strain ABW_A19 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PD64 |
| Locus tag | JJB22_RS19450 | Protein ID | WP_000854753.1 |
| Coordinates | 4120415..4120789 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | E3PJ72 |
| Locus tag | JJB22_RS19445 | Protein ID | WP_001278232.1 |
| Coordinates | 4119957..4120325 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJB22_RS19410 (4115800) | 4115800..4116480 | + | 681 | WP_001593697.1 | WYL domain-containing protein | - |
| JJB22_RS19415 (4116628) | 4116628..4117305 | + | 678 | WP_001097301.1 | hypothetical protein | - |
| JJB22_RS19420 (4117311) | 4117311..4117544 | + | 234 | WP_001278287.1 | DUF905 family protein | - |
| JJB22_RS19425 (4117643) | 4117643..4118461 | + | 819 | WP_001234631.1 | DUF932 domain-containing protein | - |
| JJB22_RS19430 (4118543) | 4118543..4119022 | + | 480 | WP_000860065.1 | antirestriction protein | - |
| JJB22_RS19435 (4119034) | 4119034..4119510 | + | 477 | WP_001186710.1 | RadC family protein | - |
| JJB22_RS19440 (4119573) | 4119573..4119794 | + | 222 | WP_000692303.1 | DUF987 domain-containing protein | - |
| JJB22_RS19445 (4119957) | 4119957..4120325 | + | 369 | WP_001278232.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| JJB22_RS19450 (4120415) | 4120415..4120789 | + | 375 | WP_000854753.1 | TA system toxin CbtA family protein | Toxin |
| JJB22_RS19455 (4120786) | 4120786..4121274 | + | 489 | WP_000777541.1 | DUF5983 family protein | - |
| JJB22_RS19460 (4121286) | 4121286..4121483 | + | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| JJB22_RS19465 (4121580) | 4121580..4122149 | + | 570 | WP_001290247.1 | DUF4942 domain-containing protein | - |
| JJB22_RS19470 (4122443) | 4122443..4123710 | + | 1268 | Protein_3859 | integrase arm-type DNA-binding domain-containing protein | - |
| JJB22_RS19475 (4123892) | 4123892..4124773 | - | 882 | WP_021577941.1 | integrase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | sul2 | - | 4081745..4123710 | 41965 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14005.00 Da Isoelectric Point: 8.2905
>T186090 WP_000854753.1 NZ_CP067307:4120415-4120789 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T186090 NZ_CP089216:c1605293-1604862 [Mycobacterium kansasii]
GTGATCATCCCCGACGTCAATCTGCTGCTGTACGCGGTCATCACGGGCTTCCCACAGCATCGGCGCGCGTACGCCTGGTG
GCACGACACCGTCAACAGCCAAGAGCGCATCGGGCTGACATACCCGGCCGTTTTCGGCTTTTTGCGTATCGTGACCAACG
CACGCATCCTCACCGAGCCCCTGTCTGCGACCGAAGCAGTCGCATATGTGCGTGACTGGCTTACGCAGCCGAACGTGGAC
CTTCTTATCCCGTCTGCCCGCCATCTGGATCTGGCATTGGGGTTGCTTGAGCAGCTCGGCACGGCCAGCAACCTGACCAC
CGACGTCCAACTGGCCGCCTACGCGATCGAGCACAACGCCGAGATGCATTCCAGCGACGCTGATTTCGCCCGATTCGCCG
GTCTCGCGTGGACCAACCCACTTGACCGATAA
GTGATCATCCCCGACGTCAATCTGCTGCTGTACGCGGTCATCACGGGCTTCCCACAGCATCGGCGCGCGTACGCCTGGTG
GCACGACACCGTCAACAGCCAAGAGCGCATCGGGCTGACATACCCGGCCGTTTTCGGCTTTTTGCGTATCGTGACCAACG
CACGCATCCTCACCGAGCCCCTGTCTGCGACCGAAGCAGTCGCATATGTGCGTGACTGGCTTACGCAGCCGAACGTGGAC
CTTCTTATCCCGTCTGCCCGCCATCTGGATCTGGCATTGGGGTTGCTTGAGCAGCTCGGCACGGCCAGCAACCTGACCAC
CGACGTCCAACTGGCCGCCTACGCGATCGAGCACAACGCCGAGATGCATTCCAGCGACGCTGATTTCGCCCGATTCGCCG
GTCTCGCGTGGACCAACCCACTTGACCGATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13491.37 Da Isoelectric Point: 6.6290
>AT186090 WP_001278232.1 NZ_CP067307:4119957-4120325 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT186090 NZ_CP089216:c1605550-1605290 [Mycobacterium kansasii]
ATGCGCACCACTTTGACGCTCGACGACGACGTCGTTCGCCTGATCGAAGAGGCTGTTCATCGCGAACGCCGCCCCATGAA
GCACGTCATCAACGACGCGCTGCGCAAAGCGTTGGCGCAGCCGATGGAACGCCGGACGCCGTATCAGTTGAAGCCGCATC
GCTCGGCAGTGCGGCCGGGATTCGATTTTGCCGGGTTCAACCGGCTGGCCGACGAGATGGAAGACCAAGCGATCCTGGAC
CAGAAGCGACCGACCCTGTGA
ATGCGCACCACTTTGACGCTCGACGACGACGTCGTTCGCCTGATCGAAGAGGCTGTTCATCGCGAACGCCGCCCCATGAA
GCACGTCATCAACGACGCGCTGCGCAAAGCGTTGGCGCAGCCGATGGAACGCCGGACGCCGTATCAGTTGAAGCCGCATC
GCTCGGCAGTGCGGCCGGGATTCGATTTTGCCGGGTTCAACCGGCTGGCCGACGAGATGGAAGACCAAGCGATCCTGGAC
CAGAAGCGACCGACCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LVU0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | E3PJ72 |