Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2496873..2497399 | Replicon | chromosome |
| Accession | NZ_CP067307 | ||
| Organism | Escherichia coli strain ABW_A19 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | JJB22_RS11615 | Protein ID | WP_000323025.1 |
| Coordinates | 2496873..2497160 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | JJB22_RS11620 | Protein ID | WP_000534858.1 |
| Coordinates | 2497160..2497399 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJB22_RS11570 (2491897) | 2491897..2492112 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| JJB22_RS26795 (2492332) | 2492332..2492502 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| JJB22_RS11575 (2492866) | 2492866..2493081 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| JJB22_RS11580 (2493382) | 2493382..2493594 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| JJB22_RS11585 (2493649) | 2493649..2493738 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| JJB22_RS11590 (2494016) | 2494016..2494768 | - | 753 | WP_001047135.1 | antitermination protein | - |
| JJB22_RS11595 (2494782) | 2494782..2495831 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| JJB22_RS11600 (2495833) | 2495833..2496111 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| JJB22_RS11605 (2496178) | 2496178..2496429 | - | 252 | WP_000980994.1 | protein Rem | - |
| JJB22_RS11610 (2496646) | 2496646..2496801 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| JJB22_RS11615 (2496873) | 2496873..2497160 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| JJB22_RS11620 (2497160) | 2497160..2497399 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| JJB22_RS11625 (2497424) | 2497424..2497729 | + | 306 | WP_001326990.1 | protein YdfV | - |
| JJB22_RS11630 (2497932) | 2497932..2498264 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| JJB22_RS27000 (2498701) | 2498701..2498850 | - | 150 | WP_011443592.1 | protein YdfW | - |
| JJB22_RS11635 (2498971) | 2498971..2500020 | - | 1050 | Protein_2305 | IS1202-like element ISEsa1 family transposase | - |
| JJB22_RS11640 (2500075) | 2500075..2500494 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| JJB22_RS11645 (2500535) | 2500535..2501500 | - | 966 | WP_000054504.1 | hypothetical protein | - |
| JJB22_RS11650 (2501481) | 2501481..2502002 | - | 522 | WP_000705349.1 | toxin YdaT family protein | - |
| JJB22_RS11655 (2501986) | 2501986..2502213 | - | 228 | WP_000476993.1 | Cro/CI family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2446119..2511655 | 65536 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T186077 WP_000323025.1 NZ_CP067307:c2497160-2496873 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T186077 NZ_CP089212:c2993103-2992684 [Nocardia asteroides]
GTGATCAGCTATCTGATCGACACATCGGCCGTCGCTCGGCTGCTGGCGAACCCCGGCGTTCGCAGGGCTTGGCAGGAGAC
GGTGACGGCCGGCGTCATCGCCGTGTGCGACGCCGTCGAACTGGAACTGTTGTTCACGGCGACGTCGCTGGCCGACCGGA
GGCGGAAGAAGGAGCTGCTGGACGACTTGTTCGGCTGGGTGCCGACGCCGGACGGGGTGTGGACGCGCGCGCAGCAGGTT
CAGCTGCTGCTCACCGAACAAGGTCATCATCGCAGTGCCGGTGTGGCAGACCTGGTGATCGCGGGCACCGCGGAGGCGAA
CCGGCTCACGGTCCTGCACTACGACCGTGACTTCGAAACGGTCGCGAAAGCGACCGGCCAGCCGACGCAATGGATCGCGC
CACCGGGAACCGTTCCCTGA
GTGATCAGCTATCTGATCGACACATCGGCCGTCGCTCGGCTGCTGGCGAACCCCGGCGTTCGCAGGGCTTGGCAGGAGAC
GGTGACGGCCGGCGTCATCGCCGTGTGCGACGCCGTCGAACTGGAACTGTTGTTCACGGCGACGTCGCTGGCCGACCGGA
GGCGGAAGAAGGAGCTGCTGGACGACTTGTTCGGCTGGGTGCCGACGCCGGACGGGGTGTGGACGCGCGCGCAGCAGGTT
CAGCTGCTGCTCACCGAACAAGGTCATCATCGCAGTGCCGGTGTGGCAGACCTGGTGATCGCGGGCACCGCGGAGGCGAA
CCGGCTCACGGTCCTGCACTACGACCGTGACTTCGAAACGGTCGCGAAAGCGACCGGCCAGCCGACGCAATGGATCGCGC
CACCGGGAACCGTTCCCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT186077 WP_000534858.1 NZ_CP067307:c2497399-2497160 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT186077 NZ_CP089212:c2993309-2993100 [Nocardia asteroides]
ATGTCCAAGCTCATGATCGAGGTCGATGACGAGGCGCTCGCCGAGGCGCAGCGACTACTGGGGACGACGACCAAGAAGGA
CACGGTCAACGCCGCGCTCGCGGAGGTGTCGCGACGGCTCAAGCGCGTCAAGGCGCTGAACGGACTGGCCGAGATGGCCG
AGCAGGGTGACTTCGACACCCTGCTGGACAAGAGCAATTATCGGCGGTGA
ATGTCCAAGCTCATGATCGAGGTCGATGACGAGGCGCTCGCCGAGGCGCAGCGACTACTGGGGACGACGACCAAGAAGGA
CACGGTCAACGCCGCGCTCGCGGAGGTGTCGCGACGGCTCAAGCGCGTCAAGGCGCTGAACGGACTGGCCGAGATGGCCG
AGCAGGGTGACTTCGACACCCTGCTGGACAAGAGCAATTATCGGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|