Detailed information of TA system TA186076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2400787..2402375
• Replicon: chromosome
• Accession: NZ_CP067307
• Organism: Escherichia coli strain ABW_A19

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A246NPH3
• Locus tag: JJB22_RS11080
• Protein ID: WP_021577463.1
• Coordinates: 2400787..2402109 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: JJB22_RS11085
• Protein ID: WP_001613070.1
• Coordinates: 2402109..2402375 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJB22_RS11060 (2396843)	2396843..2397553	-	711	WP_001195165.1	fimbria/pilus periplasmic chaperone	-
JJB22_RS11065 (2398064)	2398064..2399292	+	1229	WP_085959875.1	IS3 family transposase	-
JJB22_RS11070 (2399217)	2399217..2399813	-	597	WP_251530534.1	type 1 fimbrial major subunit FimA	-
JJB22_RS11075 (2400247)	2400247..2400516	-	270	Protein_2191	AraC family transcriptional regulator	-
JJB22_RS11080 (2400787)	2400787..2402109	-	1323	WP_021577463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
JJB22_RS11085 (2402109)	2402109..2402375	-	267	WP_001613070.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49363.02 Da
• Isoelectric Point: 8.5842

>T186076 WP_021577463.1 NZ_CP067307:c2402109-2400787 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NTERTVLLRLPLEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Nucleotide

• Length: 1323 bp

>T186076 NZ_CP089211:1611064-1611324 [Sinomicrobium kalidii]
ATGAGGTTAATTTGGTCTACAACTTCCTCGAATGATTATCTGTATTGCCAAAAAGTAGATAAAAAGATCGTCAAGCGCAT
TAATGAGTTGATAAAAAACTGTATGCGCACACCCTTTGAGGGCATAGGAAAACCCGAGGCCCTGAAAGGTGGTTTACAAG
GATATTGGTCGAGACGGATAACATCAGAACATCGGCTGGTTTATAAATACGAGGATGAAGAATTGTGGATAGCGGCCTGC
CGTTATCACTATGGGAAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10033.36 Da
• Isoelectric Point: 4.9632

>AT186076 WP_001613070.1 NZ_CP067307:c2402375-2402109 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT186076 NZ_CP089211:1610816-1611064 [Sinomicrobium kalidii]
ATGGAAACGGTAAACTACACAGACTTTCGCGCTAACCTGAAGCATTGGTTCGACAAGGTAATCAATGATGTAAGCGATAT
TGTCATTAAGCGAAAAGGAGGAAAAGACCTTGTTCTGATTTCCCTGGATGAATACAATTCATTAAAGGAGACCACCTACC
TGCTGACCGGGAAAAACAGGGATGTTTTATTGAAGTCTATTAAGGAGCTGGAAGGCGATAAAGGTGTTCAAAAAGACCTG
ATTGAATAA

Structures

Toxin

• AlphaFold DB: A0A246NPH3