Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 299688..300489 Replicon chromosome
Accession NZ_CP067307
Organism Escherichia coli strain ABW_A19

Toxin (Protein)


Gene name yeeV Uniprot ID D8EBK0
Locus tag JJB22_RS01390 Protein ID WP_001094436.1
Coordinates 299688..300065 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7MN76
Locus tag JJB22_RS01395 Protein ID WP_015953067.1
Coordinates 300112..300489 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB22_RS27175 (295915) 295915..296074 - 160 Protein_261 integrase -
JJB22_RS01370 (296459) 296459..297994 - 1536 WP_000492897.1 EAL domain-containing protein -
JJB22_RS01375 (298064) 298064..298909 - 846 WP_001280513.1 DUF4942 domain-containing protein -
JJB22_RS01380 (298994) 298994..299191 - 198 WP_000839254.1 DUF957 domain-containing protein -
JJB22_RS01385 (299203) 299203..299691 - 489 WP_000761714.1 DUF5983 family protein -
JJB22_RS01390 (299688) 299688..300065 - 378 WP_001094436.1 TA system toxin CbtA family protein Toxin
JJB22_RS01395 (300112) 300112..300489 - 378 WP_015953067.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
JJB22_RS01400 (300568) 300568..300789 - 222 WP_000692312.1 DUF987 domain-containing protein -
JJB22_RS01405 (300858) 300858..301334 - 477 WP_001186756.1 RadC family protein -
JJB22_RS01410 (301349) 301349..301834 - 486 WP_000860054.1 antirestriction protein -
JJB22_RS01415 (301925) 301925..302743 - 819 WP_001175142.1 DUF932 domain-containing protein -
JJB22_RS01420 (302833) 302833..303066 - 234 WP_001278287.1 DUF905 family protein -
JJB22_RS01425 (303072) 303072..303749 - 678 WP_001097301.1 hypothetical protein -
JJB22_RS01430 (303897) 303897..304577 - 681 WP_001593697.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13958.84 Da        Isoelectric Point: 6.8603

>T186064 WP_001094436.1 NZ_CP067307:c300065-299688 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKQ

Download         Length: 378 bp

>T186064 NZ_CP089165:802987-803253 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13766.60 Da        Isoelectric Point: 6.2021

>AT186064 WP_015953067.1 NZ_CP067307:c300489-300112 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV

Download         Length: 378 bp

>AT186064 NZ_CP089165:802730-802987 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2L1N0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z3CIS0

References