186059

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 45933..46558 Replicon plasmid pABW_A32a
Accession NZ_CP067304
Organism Escherichia coli strain ABW_A32

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JJB23_RS22325 Protein ID WP_000911313.1
Coordinates 46160..46558 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag JJB23_RS22320 Protein ID WP_000450520.1
Coordinates 45933..46160 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB23_RS22320 (45933) 45933..46160 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
JJB23_RS22325 (46160) 46160..46558 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
JJB23_RS22330 (46567) 46567..48720 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
JJB23_RS22335 (48973) 48973..49704 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
JJB23_RS22340 (49736) 49736..50233 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / blaCTX-M-65 / aac(3)-IId / sitABCD iroN / iroE / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA 1..126378 126378


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T186059 WP_000911313.1 NZ_CP067304:46160-46558 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

>T186059 NZ_CP089162:c367666-367571 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT186059 WP_000450520.1 NZ_CP067304:45933-46160 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp

>AT186059 NZ_CP089162:367484-367543 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References