186019

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3573673..3574327 Replicon chromosome
Accession NZ_CP067299
Organism Escherichia coli strain ABW_A33

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag JJB24_RS17110 Protein ID WP_000244777.1
Coordinates 3573673..3574080 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag JJB24_RS17115 Protein ID WP_000354046.1
Coordinates 3574061..3574327 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB24_RS17090 (3569630) 3569630..3571363 - 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -
JJB24_RS17095 (3571369) 3571369..3572079 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JJB24_RS17100 (3572104) 3572104..3573000 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
JJB24_RS17105 (3573112) 3573112..3573633 + 522 WP_001055874.1 flavodoxin FldB -
JJB24_RS17110 (3573673) 3573673..3574080 - 408 WP_000244777.1 protein YgfX Toxin
JJB24_RS17115 (3574061) 3574061..3574327 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
JJB24_RS17120 (3574570) 3574570..3575550 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
JJB24_RS17125 (3575746) 3575746..3576405 - 660 WP_000250274.1 hemolysin III family protein -
JJB24_RS17130 (3576569) 3576569..3576880 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
JJB24_RS17135 (3576925) 3576925..3578358 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
JJB24_RS17140 (3578415) 3578415..3579158 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T186019 WP_000244777.1 NZ_CP067299:c3574080-3573673 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T186019 NZ_CP089154:197929-198105 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT186019 WP_000354046.1 NZ_CP067299:c3574327-3574061 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT186019 NZ_CP089154:c198267-198093 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References