Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 111863..112413 Replicon plasmid pABW_S38a
Accession NZ_CP067266
Organism Escherichia coli strain ABW_S38

Toxin (Protein)


Gene name ccdB Uniprot ID S1EZ93
Locus tag JJB13_RS22955 Protein ID WP_007372286.1
Coordinates 111863..112171 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1FMC3
Locus tag JJB13_RS22960 Protein ID WP_007372285.1
Coordinates 112174..112413 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB13_RS22915 (JJB13_22910) 107054..107758 + 705 WP_001067848.1 IS6-like element IS26 family transposase -
JJB13_RS22920 (JJB13_22915) 108327..108653 - 327 WP_007372293.1 hypothetical protein -
JJB13_RS22925 (JJB13_22920) 108737..109135 - 399 WP_007372292.1 hypothetical protein -
JJB13_RS22930 (JJB13_22925) 109146..109433 - 288 WP_016241556.1 hypothetical protein -
JJB13_RS22935 (JJB13_22930) 109735..110205 - 471 WP_007372290.1 HAD domain-containing protein -
JJB13_RS22940 (JJB13_22935) 110288..110905 - 618 WP_007372289.1 hypothetical protein -
JJB13_RS22945 (JJB13_22940) 110975..111529 - 555 WP_007372288.1 hypothetical protein -
JJB13_RS22950 (JJB13_22945) 111684..111842 - 159 WP_016241558.1 hypothetical protein -
JJB13_RS22955 (JJB13_22950) 111863..112171 - 309 WP_007372286.1 CcdB family protein Toxin
JJB13_RS22960 (JJB13_22955) 112174..112413 - 240 WP_007372285.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JJB13_RS22965 (JJB13_22960) 112552..113016 - 465 WP_008786596.1 hypothetical protein -
JJB13_RS22970 (JJB13_22965) 113013..113687 - 675 WP_008786597.1 hypothetical protein -
JJB13_RS22975 (JJB13_22970) 114145..114777 - 633 WP_007372282.1 hypothetical protein -
JJB13_RS22980 (JJB13_22975) 114793..114933 - 141 WP_007372281.1 hypothetical protein -
JJB13_RS22985 (JJB13_22980) 115081..115539 - 459 WP_008786599.1 hypothetical protein -
JJB13_RS22990 (JJB13_22985) 115592..115789 - 198 WP_032155220.1 Lar family restriction alleviation protein -
JJB13_RS22995 (JJB13_22990) 115812..116507 - 696 WP_007372278.1 hypothetical protein -
JJB13_RS23000 (JJB13_22995) 116638..116829 - 192 WP_016241560.1 hypothetical protein -
JJB13_RS23005 (JJB13_23000) 117011..117406 - 396 WP_024196081.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..303836 303836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-101)

Antitoxin

(9-79)


Sequences


Toxin        


Download         Length: 103 a.a.        Molecular weight: 11351.17 Da        Isoelectric Point: 8.5044

>T185997 WP_007372286.1 NZ_CP067266:c112171-111863 [Escherichia coli]
MQYTVYRNPGNSQAYPYLLDIQSDIIGELNTRLVIPLHRLKKGASAPVARLTPVIQVEGNDVILMTHEMASVRVKQLGQA
VMDASPFRHTIKSAVDFLLDGF

Download         Length: 309 bp

>T185997 NZ_CP089142:755888-756271 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8784.97 Da        Isoelectric Point: 8.6387

>AT185997 WP_007372285.1 NZ_CP067266:c112413-112174 [Escherichia coli]
MQATAARQKKTVSVTLEPMLVQQAKDAGINLSATLAEALQSKLKASAAEEWKRQNRAGIQELNRITEEHGLLSDEYRTF

Download         Length: 240 bp

>AT185997 NZ_CP089142:755430-755798 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1EZ93


Antitoxin

Source ID Structure
AlphaFold DB S1FMC3

References