Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4182364..4182983 Replicon chromosome
Accession NZ_CP067261
Organism Klebsiella variicola strain E25

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JJB14_RS20465 Protein ID WP_002892050.1
Coordinates 4182765..4182983 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1F2MBN7
Locus tag JJB14_RS20460 Protein ID WP_008805436.1
Coordinates 4182364..4182738 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB14_RS20450 (JJB14_20445) 4177519..4178712 + 1194 WP_012542667.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JJB14_RS20455 (JJB14_20450) 4178735..4181881 + 3147 WP_008805437.1 multidrug efflux RND transporter permease subunit AcrB -
JJB14_RS20460 (JJB14_20455) 4182364..4182738 + 375 WP_008805436.1 Hha toxicity modulator TomB Antitoxin
JJB14_RS20465 (JJB14_20460) 4182765..4182983 + 219 WP_002892050.1 HHA domain-containing protein Toxin
JJB14_RS20470 (JJB14_20465) 4183142..4183708 + 567 WP_032438710.1 maltose O-acetyltransferase -
JJB14_RS20475 (JJB14_20470) 4183680..4183808 - 129 Protein_4027 hypothetical protein -
JJB14_RS20480 (JJB14_20475) 4183845..4184315 + 471 WP_008805434.1 YlaC family protein -
JJB14_RS20485 (JJB14_20480) 4184284..4185741 - 1458 WP_016160392.1 PLP-dependent aminotransferase family protein -
JJB14_RS20490 (JJB14_20485) 4185842..4186540 + 699 WP_012968815.1 GNAT family protein -
JJB14_RS20495 (JJB14_20490) 4186537..4186677 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JJB14_RS20500 (JJB14_20495) 4186677..4186940 - 264 WP_008805431.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T185971 WP_002892050.1 NZ_CP067261:4182765-4182983 [Klebsiella variicola]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T185971 NZ_CP089097:1958698-1958800 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14384.06 Da        Isoelectric Point: 4.8989

>AT185971 WP_008805436.1 NZ_CP067261:4182364-4182738 [Klebsiella variicola]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYTEDNKLVAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT185971 NZ_CP089097:c1958807-1958662 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MBN7

References