Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1581505..1582502 Replicon chromosome
Accession NZ_CP067261
Organism Klebsiella variicola strain E25

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JJB14_RS27360 Protein ID WP_233445594.1
Coordinates 1581948..1582502 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JJB14_RS07715 Protein ID WP_047666809.1
Coordinates 1581505..1581951 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB14_RS07700 (JJB14_07700) 1577800..1578798 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
JJB14_RS07705 (JJB14_07705) 1578917..1580437 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
JJB14_RS07710 (JJB14_07710) 1580453..1581463 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
JJB14_RS07715 (JJB14_07715) 1581505..1581951 - 447 WP_047666809.1 helix-turn-helix transcriptional regulator Antitoxin
JJB14_RS27360 1581948..1582502 - 555 WP_233445594.1 HipA domain-containing protein Toxin
JJB14_RS27365 1582623..1583051 - 429 WP_227507355.1 phosphatidylinositol kinase -
JJB14_RS07725 (JJB14_07725) 1583166..1583897 - 732 WP_008804033.1 outer membrane permeability protein SanA -
JJB14_RS07730 (JJB14_07730) 1584190..1585074 - 885 WP_101880685.1 cytidine deaminase -
JJB14_RS07735 (JJB14_07735) 1585203..1585898 - 696 WP_008804035.1 CidB/LrgB family autolysis modulator -
JJB14_RS07740 (JJB14_07740) 1585888..1586292 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20741.01 Da        Isoelectric Point: 5.7976

>T185959 WP_233445594.1 NZ_CP067261:c1582502-1581948 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQDFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEITLAPIYDFASMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDTLLNALRETASQLVDLPARLKARGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

>T185959 NZ_CP089094:22268-22474 [Microcystis aeruginosa FACHB-905 = DIANCHI905]
ATGAAGAGTGCTTTAATAGATACTCATGTCTTTATCTGGTTAGCTGAGGATGACCCAATTTTGCCTGTTTCGCTGCGAGA
TAGTCTTGAAAATACCGATAATGTTTTTGTAAGTATTGCTAGTTTTTGGGAAATATCGATCAAGGTAAAAATTGGTAAAC
TCTCTCTCTGTTCTGAAATGACCATGACTCAAAAAGATTGGGATTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16424.11 Da        Isoelectric Point: 10.5417

>AT185959 WP_047666809.1 NZ_CP067261:c1581951-1581505 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRVDNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp

>AT185959 NZ_CP089094:22026-22268 [Microcystis aeruginosa FACHB-905 = DIANCHI905]
ATGAGTATAGATTCAGCCCTTAAGAATATAGTTGAGAATATGCCCGATGCTCTCAAAACTGAACTTTTACATTATGCCGA
ATATTTGCTCACTAAGTCTGACCGAACAGAAGAAGATAAACAAGCAGCAAAAGAATCTGTAACTGTTAAAAGAACTTTAG
CCAGTTCAATAAAAGGAACTTTCGTTTTACCTTTAGCTAATGACTTTGATGCTCCCTTAGAAGACTTTAAGGACTATAGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References