Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 782670..783327 Replicon chromosome
Accession NZ_CP067261
Organism Klebsiella variicola strain E25

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JJB14_RS03885 Protein ID WP_002916310.1
Coordinates 782917..783327 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JJB14_RS03880 Protein ID WP_002916312.1
Coordinates 782670..782936 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB14_RS03855 (JJB14_03855) 777767..779200 - 1434 WP_110184899.1 6-phospho-beta-glucosidase BglA -
JJB14_RS03860 (JJB14_03860) 779320..780048 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
JJB14_RS03865 (JJB14_03865) 780099..780410 + 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
JJB14_RS03870 (JJB14_03870) 780574..781233 + 660 WP_008806429.1 hemolysin III family protein -
JJB14_RS03875 (JJB14_03875) 781441..782424 - 984 WP_032740987.1 tRNA-modifying protein YgfZ -
JJB14_RS03880 (JJB14_03880) 782670..782936 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JJB14_RS03885 (JJB14_03885) 782917..783327 + 411 WP_002916310.1 protein YgfX Toxin
JJB14_RS03890 (JJB14_03890) 783334..783855 - 522 WP_008806427.1 flavodoxin FldB -
JJB14_RS03895 (JJB14_03895) 783956..784852 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
JJB14_RS03900 (JJB14_03900) 784875..785588 + 714 WP_012540593.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JJB14_RS03905 (JJB14_03905) 785594..787327 + 1734 WP_032736401.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T185958 WP_002916310.1 NZ_CP067261:782917-783327 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T185958 NZ_CP089093:c166760-166488 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT185958 WP_002916312.1 NZ_CP067261:782670-782936 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT185958 NZ_CP089093:c167023-166760 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References