Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 857410..858067 Replicon chromosome
Accession NZ_CP067255
Organism Klebsiella pneumoniae strain ESBL_DR09

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JJB15_RS04230 Protein ID WP_002916310.1
Coordinates 857657..858067 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JJB15_RS04225 Protein ID WP_002916312.1
Coordinates 857410..857676 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB15_RS04200 (852618) 852618..854051 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JJB15_RS04205 (854170) 854170..854898 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JJB15_RS04210 (854948) 854948..855259 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JJB15_RS04215 (855423) 855423..856082 + 660 WP_004174454.1 hemolysin III family protein -
JJB15_RS04220 (856181) 856181..857164 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
JJB15_RS04225 (857410) 857410..857676 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JJB15_RS04230 (857657) 857657..858067 + 411 WP_002916310.1 protein YgfX Toxin
JJB15_RS04235 (858074) 858074..858595 - 522 WP_002916308.1 flavodoxin FldB -
JJB15_RS04240 (858696) 858696..859592 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JJB15_RS04245 (859615) 859615..860328 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JJB15_RS04250 (860334) 860334..862067 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T185937 WP_002916310.1 NZ_CP067255:857657-858067 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T185937 NZ_CP089065:c6117629-6117315 [Pseudomonas aeruginosa]
ATGATCTTCATCGAAACGCCAGTCTTCACGAAGCGGATTCTCGCGCTGGTAGACGACGAGACCTATCGCAAGCTTCAGGA
AGACCTAACGCTCCACCCTGACGCCGGAGTGGTCATTGAAGGCACGGGTGGCGTGCGCAAGATTCGCATTGCAGCCAATG
GCCACGGGAAAAGAGGCGGCGCCCGGGTCATCTACTACCATTTCACATCCGCCTCTCAAATTGCATTCCTGCTGGCCTAT
GACAAGGCATCGCAGGAAGATCTGACTGCCGATCAGAAAAAGATGCTTCGGCAGATCGTTGAGAACTGGAGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT185937 WP_002916312.1 NZ_CP067255:857410-857676 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT185937 NZ_CP089065:c6117312-6117007 [Pseudomonas aeruginosa]
ATGGACAAAGAACTCTTCGCTGAACTGGTCGAAAGCGTGACCCAGATGGACGAGATCGTGCGTGGCGAACGTCAACCTTC
CCGCGAGTTCCACGTCGACGCGGTGAAGGTCAAAGAAATCCGACGCGCTACTGGCCTGTCCCAGGCCAAATTCGCCCGAA
AGATCGATGTTGCTGTTGGAACCCTGCGCAATTGGGAGCAAGGGCGCCGCGATCCCGAGGGGCCTGCTCGCGCCCTGCTC
CGGGCCATTGACAATGATCCGGTTCATGTTCTGGCTGCGCTGAATGGTGGCCCGCGAGAAAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References