Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2589831..2590634 Replicon chromosome
Accession NZ_CP067245
Organism Escherichia coli strain OW1E2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6N6JYU3
Locus tag JJB17_RS12625 Protein ID WP_024156451.1
Coordinates 2590254..2590634 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5A9BSL8
Locus tag JJB17_RS12620 Protein ID WP_038807908.1
Coordinates 2589831..2590196 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB17_RS12580 (2585501) 2585501..2585902 + 402 WP_208789738.1 hypothetical protein -
JJB17_RS12585 (2585999) 2585999..2586466 + 468 WP_043017583.1 hypothetical protein -
JJB17_RS12590 (2586530) 2586530..2587063 + 534 WP_024156443.1 DUF4234 domain-containing protein -
JJB17_RS12595 (2587153) 2587153..2587404 + 252 WP_024156444.1 DUF905 family protein -
JJB17_RS12600 (2587522) 2587522..2588340 + 819 WP_024156445.1 DUF932 domain-containing protein -
JJB17_RS12605 (2588609) 2588609..2589082 + 474 WP_024156447.1 antirestriction protein -
JJB17_RS12610 (2589095) 2589095..2589574 + 480 WP_024156448.1 DNA repair protein RadC -
JJB17_RS12615 (2589588) 2589588..2589809 + 222 WP_024156449.1 DUF987 domain-containing protein -
JJB17_RS12620 (2589831) 2589831..2590196 + 366 WP_038807908.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JJB17_RS12625 (2590254) 2590254..2590634 + 381 WP_024156451.1 TA system toxin CbtA family protein Toxin
JJB17_RS12630 (2590631) 2590631..2591122 + 492 WP_024156452.1 DUF5983 family protein -
JJB17_RS24490 (2591152) 2591152..2591348 + 197 Protein_2501 hypothetical protein -
JJB17_RS12635 (2591431) 2591431..2592192 + 762 WP_208789739.1 DUF4942 domain-containing protein -
JJB17_RS12640 (2592189) 2592189..2593307 - 1119 Protein_2503 IS3 family transposase -
JJB17_RS12645 (2593368) 2593368..2593496 + 129 Protein_2504 DUF4942 domain-containing protein -
JJB17_RS12650 (2594464) 2594464..2595195 + 732 Protein_2505 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14263.44 Da        Isoelectric Point: 10.0919

>T185890 WP_024156451.1 NZ_CP067245:2590254-2590634 [Escherichia coli]
MQTLSAIPKRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEEIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS

Download         Length: 381 bp

>T185890 NZ_CP089048:c30991-30731 [Acinetobacter ursingii]
ATGAATCGGACAATTGAGTTTACAGATAACGCTTGGGATGATTATATCTACTGGCAAACGCAGGATAAAAAGGTACTCAA
GCGTATAAATGCTTTAATCAAAGAGTGCCTACGAACACCATTTGAAGGAACAGGAAAGCCCGAACCACTTAAGGCGAACC
TTTCAGGCTTTTGGAGTCGAAGGATAGATGAAAAGCATAGGTTGGTTTATGAAGTTACGGATGAACGGATTAGCATCGTT
CAGTGTCGGTTTCACTACTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13344.20 Da        Isoelectric Point: 5.8705

>AT185890 WP_038807908.1 NZ_CP067245:2589831-2590196 [Escherichia coli]
MSNPIPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPVLLKQLELMLVSGELN
PCHQHCVTLYAKGLTCEADSLGSHGYIYTAIYPTPDDSITR

Download         Length: 366 bp

>AT185890 NZ_CP089048:c31241-30975 [Acinetobacter ursingii]
ATGCAAGTATTTACATATACAGATGCACGTAACAATCTAAAATCCGTTTTAGATAAGGTTATTGATGATGCAGATGTAGC
AGTAATTACTAGGAAAGAAGGTAGTCATGCCGTTGTTATGGGGCAAGAACACTATGACAGCTTAATGGAAACTTTATATC
TTCTTTCATCTCCTAATAATGCTGCTCGTTTAAATGAGTCAATTGCCCAATTACGTGCATCCCGTACTACTGAAAGGGAT
CTCATCGAAGATGAATCGGACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N6JYU3

Antitoxin

Source ID Structure
AlphaFold DB A0A5A9BSL8

References