Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 646961..648549 Replicon chromosome
Accession NZ_CP067245
Organism Escherichia coli strain OW1E2

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag JJB17_RS03235 Protein ID WP_001125439.1
Coordinates 647227..648549 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JJB17_RS03230 Protein ID WP_001301023.1
Coordinates 646961..647227 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB17_RS03230 (646961) 646961..647227 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JJB17_RS03235 (647227) 647227..648549 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
JJB17_RS03240 (648861) 648861..649069 + 209 Protein_643 AraC family transcriptional regulator -
JJB17_RS03245 (649324) 649324..650457 + 1134 Protein_644 fimbria/pilus outer membrane usher protein -
JJB17_RS03250 (650483) 650483..651376 - 894 Protein_645 IS3 family transposase -
JJB17_RS03255 (651389) 651389..652540 - 1152 WP_001254932.1 IS30-like element IS30 family transposase -
JJB17_RS03260 (652608) 652608..652853 - 246 Protein_647 transposase -
JJB17_RS03265 (653019) 653019..653549 + 531 WP_000876763.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T185886 WP_001125439.1 NZ_CP067245:647227-648549 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T185886 NZ_CP089044:1457864-1458052 [Acinetobacter ursingii]
ATGAACAGCAAAGAAATTATTAAACGCTTAGAACAGGAAGGCTGGATCAAAGTGGGTGGTAAGGGCGACCATGAAAAATT
TAAACATCCTGAAAAATCAGGTCATGTCGTTGTACCACACCCACGTAAAGACATGCCGATCGGAACTTTGCGTAACATAT
ATAAACAAGCTGGTTGGGAATGGAGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT185886 WP_001301023.1 NZ_CP067245:646961-647227 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT185886 NZ_CP089044:1458055-1458438 [Acinetobacter ursingii]
ATGTTATATCCCGTATATGTCCATAAAGACCAAGACTCTGCTTATGGCCTAACTTTTCCTGATTTTGAAGGTTGCTTTAG
TGCTGCTGATGATATGCAGGATATTCAGCGTATGGCACAAGAGGCAGTAGAAGTGCATTTTGATGGTGAGGATCTACCCT
TACCAGAGCCATCTAGCCCTGAACAATGGATTGGTGATGATCGCTTTGAAGGAGGTTATTGGTTATTGGTCGATATTGAT
TTATCTAAAATCAGTAGTAAGTCAGTTCGGATCAATATCAGCATGCCTGAATCACTGGTTAAGCGTATTGATGCGATGGC
GAAAAAACAACATTTAAGTCGTTCGGCTTTCTTGGCGAAAAGTGCAGAGATGGCATTGCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References