Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4332477..4332999 Replicon chromosome
Accession NZ_CP067241
Organism Escherichia coli strain P19_598

Toxin (Protein)


Gene name relE Uniprot ID V0SDB6
Locus tag JJB18_RS20515 Protein ID WP_001105432.1
Coordinates 4332477..4332767 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag JJB18_RS20520 Protein ID WP_000212715.1
Coordinates 4332757..4332999 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB18_RS20500 (4327640) 4327640..4329295 + 1656 WP_001361372.1 alpha,alpha-phosphotrehalase -
JJB18_RS20505 (4329689) 4329689..4331827 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
JJB18_RS20510 (4332012) 4332012..4332476 + 465 WP_001009180.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JJB18_RS20515 (4332477) 4332477..4332767 - 291 WP_001105432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJB18_RS20520 (4332757) 4332757..4332999 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JJB18_RS20525 (4333191) 4333191..4333577 - 387 WP_001232253.1 cytochrome b562 -
JJB18_RS20530 (4333633) 4333633..4334985 - 1353 WP_001162172.1 metalloprotease PmbA -
JJB18_RS20535 (4335079) 4335079..4335630 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
JJB18_RS20540 (4335713) 4335713..4337086 - 1374 WP_001219814.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11311.21 Da        Isoelectric Point: 10.0238

>T185867 WP_001105432.1 NZ_CP067241:c4332767-4332477 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYSVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T185867 NZ_CP089036:2677523-2677678 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTGCGAATCCGAACCGGTCAGACGGAGGTCGCTGTCTTCGTAGACTACGAATCTGAGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT185867 WP_000212715.1 NZ_CP067241:c4332999-4332757 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT185867 NZ_CP089036:c2677511-2677453 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SDB6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References