Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 63188..63789 | Replicon | plasmid pSBF45b |
| Accession | NZ_CP067234 | ||
| Organism | Escherichia coli strain SBF45 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A1M0S1Q8 |
| Locus tag | JJB20_RS22865 | Protein ID | WP_024236459.1 |
| Coordinates | 63188..63568 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | JJB20_RS22870 | Protein ID | WP_001190712.1 |
| Coordinates | 63568..63789 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJB20_RS22840 (JJB20_22840) | 58628..60112 | - | 1485 | WP_000124159.1 | hypothetical protein | - |
| JJB20_RS22845 (JJB20_22845) | 60112..61305 | - | 1194 | WP_208769490.1 | terminase | - |
| JJB20_RS22850 (JJB20_22850) | 61392..61844 | - | 453 | WP_001312282.1 | late promoter-activating protein (Gp10) | - |
| JJB20_RS22855 (JJB20_22855) | 61933..62976 | - | 1044 | WP_208769491.1 | DUF968 domain-containing protein | - |
| JJB20_RS22860 (JJB20_22860) | 63004..63183 | - | 180 | WP_000113018.1 | hypothetical protein | - |
| JJB20_RS22865 (JJB20_22865) | 63188..63568 | - | 381 | WP_024236459.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| JJB20_RS22870 (JJB20_22870) | 63568..63789 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| JJB20_RS22875 (JJB20_22875) | 63862..64251 | - | 390 | WP_208769492.1 | S24 family peptidase | - |
| JJB20_RS22880 (JJB20_22880) | 64426..65007 | + | 582 | WP_208769493.1 | DNA-binding protein | - |
| JJB20_RS22885 (JJB20_22885) | 65068..65592 | - | 525 | WP_000159954.1 | toprim domain-containing protein | - |
| JJB20_RS22890 (JJB20_22890) | 65589..65894 | - | 306 | WP_000988220.1 | hypothetical protein | - |
| JJB20_RS22895 (JJB20_22895) | 65894..66178 | - | 285 | WP_208769494.1 | antitoxin PHD | - |
| JJB20_RS22900 (JJB20_22900) | 66162..66842 | - | 681 | WP_208769495.1 | hypothetical protein | - |
| JJB20_RS22905 (JJB20_22905) | 66824..67198 | - | 375 | WP_000988655.1 | hypothetical protein | - |
| JJB20_RS22910 (JJB20_22910) | 67205..67498 | - | 294 | WP_000269001.1 | hypothetical protein | - |
| JJB20_RS22915 (JJB20_22915) | 67677..67910 | - | 234 | WP_000517421.1 | hypothetical protein | - |
| JJB20_RS22920 (JJB20_22920) | 67996..68256 | - | 261 | WP_208769496.1 | eaa protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..95149 | 95149 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13643.37 Da Isoelectric Point: 5.1514
>T185811 WP_024236459.1 NZ_CP067234:c63568-63188 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVVYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVVYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
Download Length: 381 bp
>T185811 NZ_CP089032:414932-415459 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT185811 WP_001190712.1 NZ_CP067234:c63789-63568 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT185811 NZ_CP089032:414659-414925 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0S1Q8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |